Ciplon
Generic Name
Ciprofloxacin
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ciplon 200 mg injection | ৳ 95.00 | N/A |
Description
Overview of the medicine
Ciplon 200 mg Injection contains Ciprofloxacin, a fluoroquinolone antibiotic, used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
200-400 mg IV every 8-12 hours, depending on the severity and type of infection. Infuse over 60 minutes.
Elderly
Dose adjustment may be necessary based on renal function. Generally, the same as adults with normal renal function.
Renal_impairment
Dose reduction is required. For CrCl < 30 mL/min, administer 200-400 mg every 18-24 hours.
How to Take
Administer intravenously over a period of 60 minutes. Do not inject rapidly. Dilution may be required as per specific product instructions.
Mechanism of Action
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination. This leads to DNA damage and ultimately bacterial cell death.
Pharmacokinetics
Onset
Rapid, typically within 1 hour after IV administration.
Excretion
Primarily excreted renally (50-70% as unchanged drug), with some excretion via bile and feces.
Half life
Approximately 3-5 hours in adults with normal renal function.
Absorption
Rapid and well absorbed after oral administration, but for injection, it achieves high systemic concentrations quickly. Peak plasma levels are reached within 30-60 minutes after IV infusion.
Metabolism
Partially metabolized in the liver (10-20%) to less active metabolites.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones
- Concomitant use with Tizanidine (due to risk of hypotension and somnolence)
- Patients with a history of myasthenia gravis (may exacerbate muscle weakness)
Drug Interactions
Caffeine
May decrease clearance of caffeine and increase caffeine-related side effects.
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Monitor INR.
Tizanidine
Concomitant use increases tizanidine plasma concentrations, leading to hypotension and somnolence. Contraindicated.
Cyclosporine
Increased serum creatinine levels reported with concurrent use. Monitor renal function.
Theophylline
Ciprofloxacin can increase plasma levels of theophylline, leading to increased risk of toxicity (e.g., seizures). Monitor theophylline levels.
Storage
Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Limited data on overdose. Symptoms may include renal impairment, crystalluria, and reversible renal toxicity. Management involves gastric lavage, emesis, or charcoal adsorption, hydration to prevent crystalluria, and supportive care. Hemodialysis or peritoneal dialysis remove only a small amount of ciprofloxacin.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted into breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture when stored correctly.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA (USA), DGDA (Bangladesh)
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of ciprofloxacin for various bacterial infections. Ongoing research explores new indications and resistance patterns.
Lab Monitoring
- Renal function (BUN, creatinine)
- Liver function tests (ALT, AST)
- Complete blood count (CBC)
- INR (for patients on warfarin)
- Serum electrolyte levels (if risk of QT prolongation)
Doctor Notes
- Monitor renal function, especially in elderly patients or those with pre-existing kidney disease.
- Advise patients on the importance of completing the full course and reporting any adverse effects.
- Be aware of potential drug interactions, particularly with Tizanidine and Theophylline.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Report any unusual pain, tingling, numbness, or weakness immediately.
- Avoid direct sunlight or artificial UV light while on this medication.
- Inform your doctor if you have a history of heart problems or electrolyte imbalance.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is close to the time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or lightheadedness, affecting the ability to drive or operate machinery. Patients should be cautioned.
Lifestyle Advice
- Maintain good hydration to prevent crystalluria.
- Avoid excessive caffeine intake as ciprofloxacin can increase caffeine effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.