CiproCare
Generic Name
Cilocin
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Cilocin is a broad-spectrum fluoroquinolone antibiotic used to treat a wide range of bacterial infections including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and bone and joint infections.
Uses & Indications
Dosage
Adults
250-750 mg orally twice daily, depending on the infection.
Elderly
Dosage adjustment may be necessary based on renal function.
Renal_impairment
Reduced dosage required for severe renal impairment.
How to Take
Can be taken with or without food. Avoid taking with dairy products or calcium-fortified juices alone, as absorption may be reduced.
Mechanism of Action
Cilocin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.
Pharmacokinetics
Onset
1-2 hours
Excretion
Primarily excreted renally (urine) as unchanged drug and metabolites.
Half life
Approximately 4-6 hours
Absorption
Rapidly and well absorbed from the gastrointestinal tract.
Metabolism
Partially metabolized in the liver (CYP450 1A2).
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones
- Concomitant administration with Tizanidine
Drug Interactions
Warfarin
Enhanced anticoagulant effect, leading to increased bleeding risk. Monitor INR.
Tizanidine
Contraindicated due to significant blood pressure lowering and sedation.
Theophylline
Increased plasma levels of theophylline, leading to toxicity. Monitor theophylline levels.
Antacids (containing aluminum, magnesium), Iron, Zinc, Sucralfate
Reduced absorption of ciprofloxacin. Administer Cilocin 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Gastric lavage, symptomatic and supportive treatment. Hemodialysis and peritoneal dialysis are generally not effective.
Pregnancy & Lactation
Not recommended during pregnancy unless clearly necessary, as animal studies show potential for arthropathy. Excreted in breast milk, use with caution during lactation; alternative agents may be preferred.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide, hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available (patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established efficacy and safety for various bacterial infections. Ongoing post-marketing surveillance for rare adverse effects.
Lab Monitoring
- Renal function tests
- Liver function tests
- Blood counts
- INR (if on warfarin)
Doctor Notes
- Counsel patients on tendon-related risks and symptoms.
- Avoid use in patients with a history of myasthenia gravis.
- Adjust dose in renal impairment.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Stay well-hydrated.
- Avoid excessive sun exposure.
- Report any tendon pain or swelling immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or affect vision, so exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Avoid alcohol as it may exacerbate side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.