Citicol
Generic Name
Citicoline 500 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| citicol 500 mg tablet | ৳ 50.00 | ৳ 500.00 |
Description
Overview of the medicine
Citicoline is a brain chemical that occurs naturally in the body. It is used as a medicine to improve brain function, particularly in conditions like stroke, head injury, and cognitive impairment due to age or disease. It helps in the repair of damaged cell membranes and increases the levels of important neurotransmitters.
Uses & Indications
Dosage
Adults
500-2000 mg daily, typically divided into two doses. For acute stroke, 500 mg twice daily. For cognitive impairment, 500-1000 mg daily.
Elderly
No specific dose adjustment required, usually same as adults.
Renal_impairment
No specific dose adjustment necessary as excretion is not primarily renal.
How to Take
Citicoline tablets can be taken with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Citicoline is converted to cytidine and choline in the body. Choline is then used in the synthesis of acetylcholine (a neurotransmitter) and phosphatidylcholine (a component of cell membranes). It enhances phospholipid synthesis in neuronal membranes, repairs damaged cells, and has neuroprotective effects by stabilizing cell membranes and reducing free radical damage.
Pharmacokinetics
Onset
Effects may be noticed within hours for acute conditions, but cognitive benefits are usually seen after several weeks of continuous use.
Excretion
Primarily excreted as CO2 in the breath (for choline) and via urine (for cytidine and its metabolites).
Half life
The plasma half-life of choline is about 1-4 hours, while cytidine has a longer half-life after being incorporated into various cellular components.
Absorption
Well absorbed orally (>90%). Rapidly hydrolyzed in the gut wall and liver to choline and cytidine.
Metabolism
Metabolized in the liver and gut wall. Choline is incorporated into phospholipids and acetylcholine. Cytidine is incorporated into nucleic acids or catabolized.
Side Effects
Contraindications
- Hypersensitivity to citicoline or any component of the formulation.
- Conditions involving persistent hypertonia (increased muscle tone).
Drug Interactions
Levodopa
May enhance the effects of Levodopa (used in Parkinson's disease).
Meclofenoxate
Should not be administered concomitantly with meclofenoxate.
Centrophenoxine
Should not be administered concomitantly with centrophenoxine.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Citicoline has low toxicity. In case of accidental overdose, symptomatic and supportive treatment should be given.
Pregnancy & Lactation
Limited data on use during pregnancy and lactation. Should only be used if the potential benefit justifies the potential risk to the fetus or infant. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved for use in many countries as a drug, in others as a supplement
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have investigated citicoline for its efficacy in various neurological conditions, including acute ischemic stroke, cognitive impairment, and Parkinson's disease. Results are generally positive for neuroprotective and cognitive enhancing effects.
Lab Monitoring
- Routine laboratory monitoring is generally not required for citicoline.
Doctor Notes
- Consider Citicoline as an adjunct therapy for neurodegenerative diseases and post-stroke recovery.
- Monitor patient's cognitive function and neurological status periodically.
- Inform patients about the need for consistent use for optimal cognitive benefits.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking it abruptly without consulting your doctor.
- Report any unusual side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Citicoline generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or any other side effect that impairs your concentration, avoid these activities.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid excessive alcohol consumption.
- Engage in mental exercises to improve cognitive function.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.