Civox
Generic Name
Cefixime
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| civox 03 eye drop | ৳ 35.13 | N/A |
| civox 500 mg tablet | ৳ 14.05 | ৳ 84.30 |
| civox 200 mg injection | ৳ 145.00 | N/A |
| civox 200 mg suspension | ৳ 90.35 | N/A |
Description
Overview of the medicine
Civox (Cefixime) is an oral third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections, including respiratory, urinary tract, and ear infections.
Uses & Indications
Dosage
Adults
200-400 mg once daily or 200 mg twice daily, depending on infection severity.
Elderly
No dose adjustment typically required unless severe renal impairment.
Renal_impairment
Dose adjustment needed for creatinine clearance <60 mL/min (e.g., 200 mg once daily for CrCl 21-60 mL/min, 100 mg once daily for CrCl <20 mL/min).
How to Take
Can be taken with or without food. For best absorption and to reduce GI upset, take with food.
Mechanism of Action
Cefixime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs).
Pharmacokinetics
Onset
Peak plasma concentrations reached in 2-6 hours.
Excretion
Mainly through urine and bile.
Half life
3-4 hours.
Absorption
Approximately 40-50% absorbed orally.
Metabolism
Not extensively metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of anaphylactic reaction to penicillin (due to cross-reactivity)
Drug Interactions
Nifedipine
May increase Cefixime absorption.
Carbamazepine
May increase Carbamazepine levels.
Anticoagulants (e.g., Warfarin)
May increase prothrombin time; monitor INR.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose may cause GI upset (nausea, vomiting, diarrhea) and CNS effects (convulsions in susceptible patients). Treatment is symptomatic and supportive; hemodialysis or peritoneal dialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk in small amounts; use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support the efficacy and safety of Cefixime for indicated infections.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- Complete Blood Count (CBC) (for prolonged therapy)
Doctor Notes
- Advise patients to complete the full course to prevent antibiotic resistance.
- Counsel on potential gastrointestinal side effects.
- Assess renal function in elderly patients or those with pre-existing renal impairment.
Patient Guidelines
- Complete the full course of antibiotics even if symptoms improve.
- Do not share this medicine with others.
- Inform your doctor about any severe diarrhea or allergic reactions.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness; caution advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Stay hydrated during treatment.
- Avoid alcohol during antibiotic course.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.