Clarex
Generic Name
Desloratadine 5 mg
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| clarex 5 mg tablet | ৳ 2.50 | ৳ 25.00 |
Description
Overview of the medicine
Desloratadine is a non-drowsy antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy eyes, and hives.
Uses & Indications
Dosage
Adults
5 mg (one tablet) once daily, with or without food.
Elderly
No dosage adjustment is generally required, but caution should be exercised.
Renal_impairment
For patients with severe renal impairment, a starting dose of 5 mg every other day is recommended.
How to Take
Clarex tablets are for oral use and can be taken with or without food.
Mechanism of Action
Desloratadine is a selective peripheral H1-receptor antagonist. It blocks the action of histamine, a substance in the body that causes allergic symptoms, and inhibits the release of various inflammatory mediators.
Pharmacokinetics
Onset
Within 30 minutes for symptomatic relief.
Excretion
Excreted via urine and feces as conjugated metabolites.
Half life
Approximately 27 hours.
Absorption
Rapidly absorbed after oral administration, reaching peak plasma concentrations in approximately 3 hours.
Metabolism
Extensively metabolized in the liver, primarily to 3-hydroxydesloratadine, an active metabolite.
Side Effects
Contraindications
- Hypersensitivity to the active substance desloratadine, to loratadine, or to any of the excipients.
- Known allergic reaction to any component of the tablet.
Drug Interactions
Cimetidine
Minor increase in desloratadine plasma levels.
Fluoxetine
Minor increase in desloratadine plasma levels.
Erythromycin
Coadministration with erythromycin resulted in increased plasma concentrations of desloratadine.
Ketoconazole
Coadministration with ketoconazole resulted in increased plasma concentrations of desloratadine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, initiate symptomatic and supportive treatment. There is no specific antidote for desloratadine. Desloratadine is not effectively removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to the active substance desloratadine, to loratadine, or to any of the excipients.
- Known allergic reaction to any component of the tablet.
Drug Interactions
Cimetidine
Minor increase in desloratadine plasma levels.
Fluoxetine
Minor increase in desloratadine plasma levels.
Erythromycin
Coadministration with erythromycin resulted in increased plasma concentrations of desloratadine.
Ketoconazole
Coadministration with ketoconazole resulted in increased plasma concentrations of desloratadine.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, initiate symptomatic and supportive treatment. There is no specific antidote for desloratadine. Desloratadine is not effectively removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, as indicated on the packaging.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies
Patent Status
Patent expired for generic Desloratadine
Clinical Trials
Desloratadine has been extensively studied in various clinical trials demonstrating its efficacy and safety for the treatment of allergic rhinitis and chronic idiopathic urticaria across different patient populations.
Lab Monitoring
- Routine laboratory monitoring is generally not required for patients on desloratadine.
Doctor Notes
- Ensure patients understand that this is a non-sedating antihistamine and should not cause drowsiness.
- Advise patients with severe renal impairment regarding the reduced dosing frequency (every other day).
- Counsel patients on avoiding triggers for their allergic symptoms in addition to medication.
Patient Guidelines
- Do not exceed the recommended dose.
- If symptoms do not improve or worsen, consult your doctor.
- Keep all medicines out of the sight and reach of children.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Clarex (Desloratadine) is generally non-sedating, but individual responses to medication can vary. Patients should be advised to exercise caution when driving or operating machinery until they know how they react to the medicine.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain a healthy lifestyle, including adequate hydration and sleep, to support overall well-being.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.