Clavuxet
Generic Name
Amoxicillin and Clavulanic Acid Tablet
Manufacturer
Hypothetical Pharma Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| clavuxet 250 mg tablet | ৳ 30.07 | N/A |
Description
Overview of the medicine
Clavuxet-250-mg-tablet is an antibiotic medication combining amoxicillin and clavulanic acid. It is used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
One 250 mg/62.5 mg tablet every 8 hours or one 500 mg/125 mg tablet every 12 hours, depending on severity.
Elderly
No specific dose adjustment typically required unless severe renal impairment.
Renal_impairment
Dose adjustment required based on creatinine clearance; consult physician.
How to Take
Take orally at the start of a meal to minimize potential gastrointestinal intolerance and enhance absorption of clavulanic acid.
Mechanism of Action
Amoxicillin inhibits bacterial cell wall synthesis. Clavulanic acid inhibits beta-lactamase enzymes produced by bacteria, which would otherwise inactivate amoxicillin.
Pharmacokinetics
Onset
Rapid onset, typically within 1-2 hours.
Excretion
Primarily renal (urine).
Half life
Amoxicillin: 1-1.3 hours; Clavulanic acid: 1 hour.
Absorption
Well absorbed orally; food enhances absorption of clavulanate.
Metabolism
Amoxicillin is minimally metabolized; Clavulanic acid is extensively metabolized.
Side Effects
Contraindications
- History of hypersensitivity to penicillin or other beta-lactam antibiotics
- History of cholestatic jaundice or hepatic dysfunction associated with amoxicillin/clavulanic acid
Drug Interactions
Warfarin
May prolong prothrombin time; monitor INR.
Allopurinol
Increased risk of skin rash.
Methotrexate
Increased methotrexate toxicity due to reduced renal clearance.
Oral Contraceptives
May reduce efficacy of oral contraceptives.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal upset and fluid/electrolyte imbalance. Treatment is symptomatic and supportive. Hemodialysis can remove amoxicillin and clavulanate from circulation.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk; monitor infants for diarrhea, candidiasis, and skin rash.
Side Effects
Contraindications
- History of hypersensitivity to penicillin or other beta-lactam antibiotics
- History of cholestatic jaundice or hepatic dysfunction associated with amoxicillin/clavulanic acid
Drug Interactions
Warfarin
May prolong prothrombin time; monitor INR.
Allopurinol
Increased risk of skin rash.
Methotrexate
Increased methotrexate toxicity due to reduced renal clearance.
Oral Contraceptives
May reduce efficacy of oral contraceptives.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal upset and fluid/electrolyte imbalance. Treatment is symptomatic and supportive. Hemodialysis can remove amoxicillin and clavulanate from circulation.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk; monitor infants for diarrhea, candidiasis, and skin rash.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support its efficacy and safety in various bacterial infections.
Lab Monitoring
- Liver function tests (especially in patients with pre-existing hepatic impairment)
- Renal function tests (for prolonged therapy or in patients with renal impairment)
- Complete blood count (for prolonged therapy)
Doctor Notes
- Ensure patient completes full course.
- Monitor for signs of hypersensitivity, especially in patients with penicillin allergy history.
- Educate patients on potential GI side effects and taking with food.
Patient Guidelines
- Take the full course of medication, even if you feel better.
- Do not share this medication with others.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some individuals; avoid driving or operating machinery if affected.
Lifestyle Advice
- Stay hydrated.
- Maintain good hygiene to prevent further infections.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.