Claxo
Generic Name
claxo-6000-anti-xa-injection
Manufacturer
Claxo Pharma Inc.
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| claxo 6000 anti xa injection | ৳ 600.00 | N/A |
Description
Overview of the medicine
Claxo-6000-anti-Xa-injection is an anticoagulant medicine containing a low molecular weight heparin (LMWH) analog. It is used to prevent and treat various thromboembolic disorders.
Uses & Indications
Dosage
Adults
Varies based on indication, typically 6000 anti-Xa IU once or twice daily for prophylaxis, higher doses for treatment.
Elderly
Dose adjustments may be necessary due to increased risk of bleeding and renal impairment.
Renal_impairment
Significant dose reduction recommended for severe renal impairment (CrCl <30 mL/min).
How to Take
Administer by subcutaneous injection into the anterolateral or posterolateral abdominal wall, or alternatively into the thigh. Intravenous administration may be used for specific indications like hemodialysis.
Mechanism of Action
Claxo-6000-anti-Xa-injection exerts its anticoagulant effect primarily by potentiating the action of antithrombin III, thereby accelerating the inhibition of Factor Xa. It has a high anti-Factor Xa to anti-Factor IIa activity ratio.
Pharmacokinetics
Onset
Immediate after IV, 1-3 hours after SC
Excretion
Primarily renal excretion as unchanged drug and metabolites.
Half life
Approximately 4-6 hours for anti-Xa activity following a single SC dose.
Absorption
Rapid and complete absorption after subcutaneous (SC) administration, with peak anti-Xa activity achieved within 3-5 hours.
Metabolism
Partially depolymerized in the liver.
Side Effects
Contraindications
- Active major bleeding
- History of heparin-induced thrombocytopenia (HIT) with or without thrombosis
- Hypersensitivity to the active substance or any excipients
- Acute bacterial endocarditis
- Severe uncontrolled hypertension
Drug Interactions
Other heparins or thrombolytics
Increased risk of bleeding.
Oral anticoagulants (e.g., warfarin)
Concurrent use requires careful monitoring and bridging therapy.
Antiplatelet agents (e.g., aspirin, clopidogrel, NSAIDs)
Increased risk of bleeding.
Storage
Store below 25°C. Do not freeze. Protect from light.
Overdose
Symptoms include bleeding. Management involves discontinuing the drug. Protamine sulfate can be used as an antidote to neutralize the anticoagulant effect.
Pregnancy & Lactation
Use with caution during pregnancy, especially in the first trimester; consult a doctor. Excreted into breast milk in small amounts; generally considered compatible with breastfeeding, but consult a doctor.
Side Effects
Contraindications
- Active major bleeding
- History of heparin-induced thrombocytopenia (HIT) with or without thrombosis
- Hypersensitivity to the active substance or any excipients
- Acute bacterial endocarditis
- Severe uncontrolled hypertension
Drug Interactions
Other heparins or thrombolytics
Increased risk of bleeding.
Oral anticoagulants (e.g., warfarin)
Concurrent use requires careful monitoring and bridging therapy.
Antiplatelet agents (e.g., aspirin, clopidogrel, NSAIDs)
Increased risk of bleeding.
Storage
Store below 25°C. Do not freeze. Protect from light.
Overdose
Symptoms include bleeding. Management involves discontinuing the drug. Protamine sulfate can be used as an antidote to neutralize the anticoagulant effect.
Pregnancy & Lactation
Use with caution during pregnancy, especially in the first trimester; consult a doctor. Excreted into breast milk in small amounts; generally considered compatible with breastfeeding, but consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, check specific packaging.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in various clinical trials demonstrating efficacy and safety in VTE prophylaxis and treatment.
Lab Monitoring
- Complete Blood Count (CBC) including platelet count
- Anti-Xa levels (for specific populations/high doses)
- Renal function tests (e.g., creatinine, CrCl)
- Liver function tests (LFTs)
Doctor Notes
- Careful patient selection and monitoring are crucial.
- Assess bleeding risk factors before initiating therapy.
- Educate patients on injection technique and bleeding signs.
Patient Guidelines
- Do not inject intramuscularly.
- Rotate injection sites.
- Report any unusual bleeding or bruising immediately.
- Inform your doctor about all medications you are taking.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Does not generally affect the ability to drive or operate machinery. However, if you experience side effects like dizziness, avoid driving.
Lifestyle Advice
- Avoid activities that increase the risk of injury or bleeding.
- Maintain regular follow-up appointments.
- Carry an identification card stating you are on anticoagulant therapy.
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