Clecof
Generic Name
Dextromethorphan Hydrobromide + Guaifenesin
Manufacturer
Alpha Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| clecof 100 mg syrup | ৳ 80.00 | N/A |
Description
Overview of the medicine
Clecof-100-mg syrup is a combination medication used to relieve cough and chest congestion caused by the common cold, bronchitis, and other breathing illnesses. It works by loosening mucus in the lungs and making it easier to cough up, while also suppressing the cough reflex.
Uses & Indications
Dosage
Adults
Adults and children 12 years and older: 10 mL (2 teaspoonfuls) orally every 4 hours, not to exceed 60 mL in 24 hours. Children 6 to under 12 years: 5 mL (1 teaspoonful) every 4 hours, not to exceed 30 mL in 24 hours. Children 2 to under 6 years: 2.5 mL (1/2 teaspoonful) every 4 hours, not to exceed 15 mL in 24 hours. Not for children under 2 years.
Elderly
No specific dosage adjustment needed, but caution advised for those with compromised renal or hepatic function. Always consult a physician.
Renal_impairment
Use with caution. Dosage reduction may be necessary in severe renal impairment. Consult a physician.
How to Take
Take orally, measure with a dosing spoon or cup. Do not dilute. May be taken with or without food. Drink plenty of fluids to help loosen congestion.
Mechanism of Action
Dextromethorphan acts on the cough center in the medulla oblongata to elevate the cough threshold, thereby suppressing the cough reflex. Guaifenesin is an expectorant that works by increasing the volume and decreasing the viscosity of secretions in the trachea and bronchi, thereby making it easier to remove by coughing.
Pharmacokinetics
Onset
Dextromethorphan: 15-30 minutes; Guaifenesin: ~30 minutes
Excretion
Mainly renal (urine) as metabolites.
Half life
Dextromethorphan: 2-4 hours (extensive metabolizers), up to 45 hours (poor metabolizers); Guaifenesin: ~1 hour
Absorption
Rapidly absorbed from the gastrointestinal tract. Dextromethorphan undergoes rapid and extensive first-pass metabolism.
Metabolism
Dextromethorphan: Hepatic, primarily via CYP2D6 to dextrorphan (active metabolite); Guaifenesin: Hepatic, to beta-(2-methoxyphenoxy)lactic acid.
Side Effects
Contraindications
- Hypersensitivity to dextromethorphan, guaifenesin, or any component of the formulation
- Concurrent use or within 14 days of discontinuing MAO inhibitors
- Children under 2 years of age
Drug Interactions
SSRIs/TCAs
Increased risk of serotonin syndrome when used with dextromethorphan.
MAO Inhibitors
Concurrent use can lead to serious, sometimes fatal, reactions including serotonin syndrome (fever, rigidity, mental status changes). Avoid within 14 days of MAOI use.
Alcohol/CNS Depressants
May enhance CNS depressant effects of dextromethorphan.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, drowsiness, dizziness, blurred vision, nystagmus, lethargy, respiratory depression, and serotonin syndrome (with MAOIs or SSRIs). Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Consult a doctor before use. Limited data available on excretion into breast milk. Use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved for OTC use in many countries, Prescription-only in some regions (DGDA approved)
Patent Status
Generically available (active ingredients are off-patent)
Clinical Trials
Well-established ingredients. Clinical trials support the efficacy of dextromethorphan as an antitussive and guaifenesin as an expectorant for acute cough.
Lab Monitoring
- No routine lab monitoring required for typical use.
- Monitor for signs of serotonin syndrome if co-administered with other serotonergic agents.
Doctor Notes
- Advise patients against using for chronic cough without diagnosis.
- Educate on potential for abuse with dextromethorphan.
- Review concomitant medications for potential drug interactions, especially serotonergic agents.
Patient Guidelines
- Do not exceed recommended dose.
- Do not use for persistent or chronic cough (e.g., due to smoking, asthma, emphysema) or if cough is accompanied by excessive phlegm (mucus), unless directed by a doctor.
- Stop use and consult a doctor if cough lasts more than 7 days, comes back, or is accompanied by fever, rash, or persistent headache.
- Avoid driving or operating machinery if experiencing drowsiness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause drowsiness or dizziness. If affected, do not drive or operate heavy machinery.
Lifestyle Advice
- Drink plenty of fluids to help thin mucus.
- Use a humidifier to moisten the air.
- Avoid irritants like smoke and dust.
- Get adequate rest.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.