Cleomycin
Generic Name
Cleomycin
Manufacturer
MediPharm Inc.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cleomycin 300 mg capsule | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Cleomycin 300 mg capsule is an anti-cancer medication used to treat certain types of cancer. It works by slowing or stopping the growth of cancer cells by interfering with their DNA.
Uses & Indications
Dosage
Adults
Dosage depends on the type of cancer and patient condition. Typically, 300 mg orally once daily or as directed by a physician.
Elderly
Lower starting doses may be considered, and renal function should be monitored.
Renal_impairment
Dose reduction may be necessary in patients with severe renal impairment.
How to Take
Take the capsule orally with a glass of water, either 1 hour before or 2 hours after a meal. Do not crush or chew the capsule.
Mechanism of Action
Cleomycin causes DNA strand breaks and inhibits DNA synthesis, thereby preventing cancer cell proliferation. It primarily acts on cells in the G2 and M phases of the cell cycle.
Pharmacokinetics
Onset
Onset of action within 1-2 hours.
Excretion
Primarily excreted unchanged via the kidneys.
Half life
Plasma half-life of 2-4 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract after oral administration.
Metabolism
Partially metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Cleomycin or any of its components
- Severe pulmonary disease
Drug Interactions
Nephrotoxic drugs
May enhance renal damage.
Other cytotoxic agents
May increase toxicity.
Storage
Store in a cool, dry place below 25°C, away from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, there is no specific antidote. Symptomatic and supportive treatment should be provided, with close monitoring of vital signs and organ function.
Pregnancy & Lactation
Cleomycin should not be used during pregnancy or lactation as it may cause fetal harm or be excreted in breast milk. Effective contraception should be used during treatment and for a specified period thereafter.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Worldwide
Approval Status
Approved
Patent Status
Patented
Clinical Trials
Phase III clinical trials successfully completed.
Lab Monitoring
- Pulmonary Function Tests (PFTs)
- Renal Function Tests (RFTs)
- Complete Blood Count (CBC)
- Liver Function Tests (LFTs)
Doctor Notes
- Monitor patients closely for signs of pulmonary toxicity.
- Renal function and complete blood counts should be regularly checked.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Report any unusual symptoms or side effects to your doctor immediately.
- Attend regular follow-up visits and undergo necessary tests.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medication may cause fatigue or dizziness in some patients. Avoid driving or operating heavy machinery if you experience these effects.
Lifestyle Advice
- Avoid smoking and alcohol consumption.
- Maintain a healthy and balanced diet.
- Stay hydrated by drinking plenty of fluids.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.