Clindax-Plus
Generic Name
Clindamycin 1.2% w/w + Tretinoin 0.025% w/w Topical Gel
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| clindax plus 12 0025 topical gel | ৳ 150.00 | N/A |
Description
Overview of the medicine
Clindax-Plus is a combination topical gel containing Clindamycin and Tretinoin, used for the treatment of acne vulgaris. It works by reducing bacteria and promoting normal skin cell turnover.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected area once daily, usually in the evening/at night, after washing and drying the skin.
Elderly
No specific dosage adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is considered necessary for patients with renal impairment, as systemic absorption is minimal.
How to Take
For external use only. Apply to clean, dry skin. Avoid contact with eyes, lips, nostrils, and other mucous membranes. If contact occurs, rinse thoroughly with water. Wash hands thoroughly after application.
Mechanism of Action
Clindamycin inhibits bacterial protein synthesis, thereby reducing the growth of *Cutibacterium acnes* (formerly *Propionibacterium acnes*). Tretinoin (retinoic acid) modifies abnormal follicular keratinization, promotes comedolysis, and has anti-inflammatory effects, leading to a reduction in acne lesions.
Pharmacokinetics
Onset
Clinical improvement usually observed within 2-4 weeks, with optimal results after 8-12 weeks of continuous use.
Excretion
Minimal systemic excretion. Any absorbed clindamycin is excreted via urine and feces. Tretinoin metabolites are excreted via bile and urine.
Half life
Not clinically relevant for topical use due to minimal systemic absorption.
Absorption
Minimal systemic absorption of both clindamycin and tretinoin when applied topically.
Metabolism
Minimal systemic metabolism for topical application. Any absorbed clindamycin is primarily metabolized in the liver. Tretinoin is primarily metabolized to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to clindamycin, tretinoin, lincomycin, or any component of the gel.
- •History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis.
- •Pregnancy (due to tretinoin component).
Drug Interactions
Topical erythromycin
May antagonize the action of clindamycin.
Other topical acne therapies
Concurrent use with other topical preparations (e.g., benzoyl peroxide, salicylic acid, sulfur, resorcinol) may cause excessive skin irritation, dryness, or peeling. Use with caution or avoid.
Neuromuscular blocking agents
Clindamycin has neuromuscular blocking properties; use with caution in patients receiving such agents.
Storage
Store below 25°C (77°F). Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose is unlikely with topical application. If accidentally ingested, medical advice should be sought immediately. Management is supportive.
Pregnancy & Lactation
Pregnancy: Contraindicated due to the tretinoin component, which is a known teratogen. Women of childbearing potential should use effective contraception during treatment. Lactation: Use with caution. It is unknown if clindamycin or tretinoin are excreted in human milk after topical application. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture, depending on manufacturer specifications.
Availability
Pharmacies, Drugstores
Approval Status
DGDA Approved
Patent Status
Off-patent (Generic available)
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Global Brand Names
International brand names for this medicine
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