Clinosol Vit Infusion
Generic Name
Clinosol Vit
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Clinosol Vit is an intravenous solution containing amino acids, vitamins, and electrolytes, primarily used for providing complete or partial parenteral nutrition to patients who cannot receive adequate nutrition orally or enterally.
Uses & Indications
Dosage
Adults
Highly individualized, based on patient's metabolic needs, weight, clinical condition, and fluid status. Typically administered as a continuous intravenous infusion under medical supervision.
Elderly
Careful monitoring and slower infusion rates may be necessary due to potential reduced renal or hepatic function.
Renal_impairment
Dosage requires careful adjustment, especially regarding electrolyte content and fluid volume. Close monitoring of renal function and electrolyte levels is essential.
How to Take
Administered by slow, continuous intravenous infusion using an appropriate infusion pump, under strict aseptic conditions. Regular monitoring of the infusion site is crucial.
Mechanism of Action
Provides essential amino acids for protein synthesis, vitamins for metabolic co-factor roles, and electrolytes for maintaining fluid balance and cellular function, thereby supporting overall physiological processes.
Pharmacokinetics
Onset
Immediate due to direct intravenous administration.
Excretion
Excess water and electrolytes are primarily excreted by the kidneys. Some vitamin metabolites are also excreted renally.
Half life
Variable for individual components; amino acids are rapidly utilized, electrolytes are regulated by renal excretion, vitamins have varied half-lives.
Absorption
Administered intravenously, hence 100% bioavailability directly into systemic circulation.
Metabolism
Amino acids are metabolized in liver and other tissues for protein synthesis or energy; vitamins participate in various metabolic pathways; electrolytes are largely excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to any component of the solution.
- Severe untreated electrolyte disturbances (e.g., hyperkalemia, hypernatremia).
- Severe fluid overload (hyperhydration).
- Unstable metabolic conditions (e.g., severe acidosis, severe hyperglycemia).
Drug Interactions
0
Tetracycline antibiotics: May interact with calcium and phosphate, forming insoluble complexes.
1
Warfarin: Large amounts of Vitamin K in some formulations may counteract anticoagulant effects.
2
Certain diuretics: Can alter electrolyte balance, requiring closer monitoring.
3
Other IV additives: Risk of precipitation or incompatibility when mixing with other medications.
Storage
Store below 25°C, protected from light. Do not freeze. Administer immediately after opening.
Overdose
Symptoms of overdose may include fluid overload, severe electrolyte imbalances (e.g., hyperkalemia, hypernatremia), hyperglycemia, and metabolic acidosis. Management involves discontinuing the infusion, symptomatic treatment, and correction of fluid and electrolyte imbalances.
Pregnancy & Lactation
Should only be used during pregnancy or lactation if the potential benefits outweigh the potential risks to the fetus or infant, and under strict medical supervision. Nutritional support is often crucial in these conditions.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 1-2 years when stored correctly, refer to product label for specific details.
Availability
Hospitals, clinics, and specialized pharmacies
Approval Status
DGDA approved
Patent Status
Off-patent (Generic)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials support the efficacy and safety of parenteral nutrition solutions in various patient populations requiring nutritional support.
Lab Monitoring
- Daily monitoring of serum electrolytes (sodium, potassium, calcium, magnesium, phosphate).
- Blood glucose levels (especially at initiation and during dosage adjustments).
- Liver function tests (ALT, AST, bilirubin) and renal function tests (BUN, creatinine).
- Fluid balance, weight, and complete blood count.
Doctor Notes
- Individualize dosage based on patient's clinical status, metabolic needs, and laboratory parameters.
- Ensure strict aseptic technique during catheter insertion and solution administration to prevent infections.
- Closely monitor for signs of fluid overload, electrolyte imbalances, and hyperglycemia, especially during initiation and changes in therapy.
Patient Guidelines
- This medication is administered by healthcare professionals in a hospital or clinical setting.
- Patients should report any discomfort, pain, or redness at the infusion site immediately.
- Regular blood tests will be conducted to monitor the body's response to the nutrition.
Missed Dose Advice
As this is typically a continuous infusion in a hospital setting, interruptions should be managed immediately by healthcare professionals. Do not attempt to self-adjust or compensate for missed infusions.
Driving Precautions
As Clinosol Vit is typically administered to hospitalized patients with underlying medical conditions, driving or operating machinery is not recommended.
Lifestyle Advice
- Not directly applicable to the patient in terms of self-management as it's an administered therapy. Focus is on clinical management.
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Global Brand Names
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