Clobecort
Generic Name
Clobetasol Propionate
Manufacturer
Healthcare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| clobecort 005 cream | ৳ 75.00 | N/A |
Description
Overview of the medicine
Clobecort 0.05% Cream contains clobetasol propionate, a potent topical corticosteroid, used to treat various inflammatory skin conditions such as eczema, psoriasis, and dermatitis. It works by reducing inflammation, itching, and redness.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area once or twice daily. Do not use for more than 2 consecutive weeks.
Elderly
Use with caution, similar to adult dose but monitor for skin atrophy.
Renal_impairment
No specific dosage adjustment required for topical use, but systemic absorption should be minimized.
How to Take
For external use only. Apply a thin layer to the affected skin area and rub in gently. Wash hands after use. Avoid contact with eyes, face, and mucous membranes. Do not use on large areas or under occlusive dressings unless advised by a doctor.
Mechanism of Action
Clobetasol propionate is a potent corticosteroid that works by activating natural substances in the skin to reduce swelling, redness, and itching. It inhibits the release of various inflammatory mediators, including prostaglandins and leukotrienes, and suppresses immune responses.
Pharmacokinetics
Onset
Symptom relief usually within days.
Excretion
Primarily through urine and feces as metabolites.
Half life
Not well established for topical application; systemic half-life of absorbed drug is several hours.
Absorption
Minimal systemic absorption through intact skin; increased absorption with occlusive dressings, inflamed skin, or prolonged use.
Metabolism
Primarily in the liver by CYP3A4.
Side Effects
Contraindications
- Known hypersensitivity to clobetasol propionate or any excipients
- Rosacea
- Acne vulgaris
- Perioral dermatitis
- Pruritus without inflammation
- Perianal and genital pruritus
- Primary cutaneous viral infections (e.g., herpes simplex, chickenpox)
- Fungal or bacterial skin infections (without concomitant anti-infective therapy)
- Children under 12 years (unless specifically indicated)
Drug Interactions
CYP3A4 inhibitors
Co-administration with potent CYP3A4 inhibitors (e.g., ritonavir, itraconazole) may increase systemic exposure to clobetasol propionate, increasing the risk of systemic side effects.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause acute systemic problems. Chronic overdose or misuse may lead to symptoms of hypercorticism (e.g., Cushing's syndrome) and adrenal suppression. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Category C in pregnancy. Use only if the potential benefit justifies the potential risk to the fetus. Use with caution during lactation; avoid application to the breast area. Consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to clobetasol propionate or any excipients
- Rosacea
- Acne vulgaris
- Perioral dermatitis
- Pruritus without inflammation
- Perianal and genital pruritus
- Primary cutaneous viral infections (e.g., herpes simplex, chickenpox)
- Fungal or bacterial skin infections (without concomitant anti-infective therapy)
- Children under 12 years (unless specifically indicated)
Drug Interactions
CYP3A4 inhibitors
Co-administration with potent CYP3A4 inhibitors (e.g., ritonavir, itraconazole) may increase systemic exposure to clobetasol propionate, increasing the risk of systemic side effects.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause acute systemic problems. Chronic overdose or misuse may lead to symptoms of hypercorticism (e.g., Cushing's syndrome) and adrenal suppression. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Category C in pregnancy. Use only if the potential benefit justifies the potential risk to the fetus. Use with caution during lactation; avoid application to the breast area. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Clobetasol propionate has undergone extensive clinical trials demonstrating its efficacy in treating severe inflammatory dermatoses. Studies focus on its rapid onset of action and potent anti-inflammatory effects. Ongoing research includes studies on optimal duration of use and managing long-term side effects.
Lab Monitoring
- HPA axis suppression (e.g., plasma cortisol levels) for prolonged or extensive use, especially in children.
Doctor Notes
- Emphasize short-term use for severe conditions.
- Educate patients on proper application technique and avoiding facial/intertriginous areas.
- Monitor for signs of skin atrophy and systemic absorption.
- Consider step-down therapy or intermittent use for chronic conditions.
Patient Guidelines
- Use exactly as directed by your doctor.
- Do not use for longer than prescribed.
- Avoid contact with eyes and mouth.
- Do not cover the treated area with bandages or other dressings unless directed by your doctor.
- Inform your doctor if your condition worsens or does not improve within two weeks.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra to make up for the missed dose.
Driving Precautions
Unlikely to affect ability to drive or operate machinery, as it is a topical preparation with minimal systemic absorption.
Lifestyle Advice
- Maintain good skin hygiene.
- Avoid irritants and allergens.
- Keep skin moisturized if dryness occurs.
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Global Brand Names
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