Clobid
Generic Name
Clopidogrel
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| clobid 10 mg tablet | ৳ 3.00 | N/A |
Description
Overview of the medicine
Clobid contains Clopidogrel, an antiplatelet agent used to prevent blood clots in patients with cardiovascular disease, recent heart attack, stroke, or peripheral arterial disease.
Uses & Indications
Dosage
Adults
For ACS (STEMI/NSTEMI/UA): Loading dose of 300 mg or 600 mg, followed by 75 mg once daily. For MI/stroke/PAD: 75 mg once daily.
Elderly
No specific dose adjustment is generally needed based on age alone.
Renal_impairment
No dose adjustment generally required for mild to moderate renal impairment. Caution advised in severe impairment due to limited data.
How to Take
Administer orally, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor (P2Y12), thereby inhibiting ADP-mediated platelet activation and aggregation.
Pharmacokinetics
Onset
Antiplatelet effect begins within 2 hours of a single dose, maximal effect observed in 3-7 days with repeated dosing.
Excretion
Approximately 50% via urine and 46% via feces within 5 days of administration.
Half life
Parent compound has a half-life of approximately 6 hours. The active metabolite has a very short half-life (< 1 hour).
Absorption
Rapidly absorbed after oral administration, bioavailability is about 50% for the parent drug.
Metabolism
Extensively metabolized in the liver by CYP450 enzymes (primarily CYP2C19) to an active thiol metabolite and inactive carboxylic acid derivatives.
Side Effects
Contraindications
- Active pathological bleeding (e.g., peptic ulcer, intracranial hemorrhage)
- Hypersensitivity to Clopidogrel or any component of the product
- Severe liver impairment
Drug Interactions
0
Warfarin: Increased risk of bleeding, concomitant use not recommended.
1
NSAIDs (e.g., Aspirin, Ibuprofen): Increased risk of gastrointestinal bleeding.
2
Proton Pump Inhibitors (PPIs) (e.g., Omeprazole, Esomeprazole): May reduce the antiplatelet effect of clopidogrel via CYP2C19 inhibition. Avoid concomitant use.
3
SSRIs/SNRIs: Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose may lead to prolonged bleeding time and subsequent bleeding complications. There is no specific antidote. Management is supportive and symptomatic, including platelet transfusion if severe bleeding occurs.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but human data are limited. Use only if clearly needed. It is unknown if Clopidogrel is excreted in human milk; use during lactation is generally not recommended due to potential for adverse effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials (e.g., CAPRIE, CURE, COMMIT/CCS-2, CREDO) have demonstrated the efficacy of Clopidogrel in reducing cardiovascular events in patients at risk.
Lab Monitoring
- Complete Blood Count (CBC) with platelet count (especially if bleeding occurs or TTP is suspected)
- Bleeding time (if clinically indicated)
- Liver function tests (in patients with hepatic impairment)
Doctor Notes
- Carefully assess bleeding risk before initiating and during clopidogrel therapy.
- Avoid concomitant use with strong CYP2C19 inhibitors and other agents that increase bleeding risk.
- Educate patients on the importance of adherence and signs of bleeding.
- Consider genetic testing for CYP2C19 in selected high-risk patients, especially if treatment failure is suspected.
Patient Guidelines
- Take Clobid exactly as prescribed by your doctor, do not stop without consultation.
- Report any signs of unusual bleeding or bruising immediately to your doctor.
- Inform all healthcare providers (including dentists) that you are taking Clobid before any surgery or procedure.
- Avoid activities with a high risk of injury to prevent bleeding.
Missed Dose Advice
If a dose is missed by less than 12 hours, take it as soon as remembered. If more than 12 hours have passed, skip the missed dose and resume your regular schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Clobid is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness, avoid driving or operating machinery.
Lifestyle Advice
- Be cautious with sharp objects (e.g., razors, nail clippers) to avoid cuts.
- Limit alcohol consumption as it may increase the risk of stomach bleeding.
- Avoid NSAIDs (non-steroidal anti-inflammatory drugs) unless advised by your doctor due to increased bleeding risk.
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Global Brand Names
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