Cloradex
Generic Name
Chloramphenicol 0.5% & Dexamethasone 0.1% Eye Drop
Manufacturer
Example Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cloradex 01 05 eye drop | ৳ 70.00 | N/A |
Description
Overview of the medicine
Cloradex eye drop is a combination medication containing an antibiotic (Chloramphenicol) and a corticosteroid (Dexamethasone). It is used to treat bacterial eye infections where inflammation is also present.
Uses & Indications
Dosage
Adults
1-2 drops into the affected eye(s) 3-4 times daily or as directed by the physician.
Elderly
No specific dosage adjustment required, use with caution.
Renal_impairment
No dosage adjustment needed due to minimal systemic absorption.
How to Take
Wash hands before use. Tilt head back, pull down lower eyelid to form a pouch. Instill drops without touching the eye with the dropper tip. Close eye gently for 1-2 minutes. Do not rinse the dropper.
Mechanism of Action
Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. Dexamethasone is a potent synthetic corticosteroid that suppresses inflammation by inhibiting various inflammatory mediators.
Pharmacokinetics
Onset
Anti-inflammatory effects of Dexamethasone may begin within hours. Antibiotic effects of Chloramphenicol within 24-48 hours.
Excretion
Locally metabolized and excreted via normal ocular fluid turnover. Minimal systemic excretion.
Half life
Not significant for ocular application due to minimal systemic absorption.
Absorption
Minimal systemic absorption occurs after ocular administration. Local absorption into ocular tissues.
Metabolism
Primarily local metabolism in ocular tissues; systemic metabolism (hepatic) for absorbed components is negligible.
Side Effects
Contraindications
- Hypersensitivity to Chloramphenicol, Dexamethasone, or any component of the formulation
- Viral or fungal eye infections
- Untreated parasitic infections
- Mycobacterial infections of the eye
- Glaucoma or ocular hypertension (unless specifically prescribed and monitored)
Drug Interactions
Immunosuppressants
May increase the risk of systemic effects of Dexamethasone with prolonged use.
Other ophthalmic preparations
Administer with an interval of at least 5-10 minutes.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Ocular overdose is unlikely to cause systemic toxicity. If excessive drops are applied, rinse the eye with lukewarm water. If accidentally ingested, seek medical attention.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and the potential benefits outweigh the potential risks. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Chloramphenicol, Dexamethasone, or any component of the formulation
- Viral or fungal eye infections
- Untreated parasitic infections
- Mycobacterial infections of the eye
- Glaucoma or ocular hypertension (unless specifically prescribed and monitored)
Drug Interactions
Immunosuppressants
May increase the risk of systemic effects of Dexamethasone with prolonged use.
Other ophthalmic preparations
Administer with an interval of at least 5-10 minutes.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Ocular overdose is unlikely to cause systemic toxicity. If excessive drops are applied, rinse the eye with lukewarm water. If accidentally ingested, seek medical attention.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and the potential benefits outweigh the potential risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months unopened. Discard 28 days after opening.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Studies have shown efficacy in reducing bacterial load and inflammation in common ocular infections. Refer to published literature for details.
Lab Monitoring
- Intraocular pressure (IOP) monitoring for prolonged corticosteroid use.
- Regular eye examination by an ophthalmologist.
Doctor Notes
- Emphasize limited duration of use due to corticosteroid component.
- Monitor for signs of increased IOP or secondary infection.
- Educate patients on proper instillation technique.
Patient Guidelines
- Do not wear contact lenses during treatment.
- Avoid contaminating the dropper tip.
- Complete the full course of treatment as prescribed.
- If symptoms worsen or do not improve within a few days, consult your doctor.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
May cause temporary blurred vision after application. Avoid driving or operating machinery until vision clears.
Lifestyle Advice
- Maintain good eye hygiene.
- Avoid rubbing eyes.
- Wear sunglasses outdoors if sensitive to light.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.