Closon
Generic Name
Clobetasol Propionate 0.05% w/w Cream
Manufacturer
Reputable Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| closon 005 1 cream | ৳ 30.00 | N/A |
Description
Overview of the medicine
Closon 0.05% w/w Cream contains clobetasol propionate, a very potent topical corticosteroid. It is used for the short-term treatment of inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses, such as psoriasis, recalcitrant eczemas, lichen planus, discoid lupus erythematosus, and other conditions that have not responded satisfactorily to less potent steroids.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area once or twice daily for up to 4 weeks. Do not use for more than 4 weeks; if further treatment is needed, consider a less potent corticosteroid. Max dose 50g per week.
Elderly
Same as adults, but use with caution due to thinner skin and increased potential for systemic absorption.
Renal_impairment
No specific dosage adjustment recommended for topical use; however, use with caution if extensive skin involvement or prolonged treatment due to potential systemic absorption.
How to Take
For external use only. Apply a thin layer to the affected skin area and rub in gently. Wash hands immediately after application, unless hands are the treated area. Do not cover the treated area with occlusive dressings unless specifically instructed by a doctor.
Mechanism of Action
Clobetasol propionate exerts its therapeutic effects by inducing phospholipase A2 inhibitory proteins, collectively called lipocortins. It is thought that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Pharmacokinetics
Onset
Clinical effects typically begin within hours of application.
Excretion
Metabolites are excreted primarily by the kidneys, and to a lesser extent, in the bile.
Half life
Systemic half-life of absorbed clobetasol is not well established for topical use but is generally short, similar to other corticosteroids (several hours).
Absorption
The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Systemic absorption can occur, especially with prolonged use, application to large surface areas, or under occlusive dressings. Inflamed and/or diseased skin may increase absorption.
Metabolism
Once absorbed, clobetasol propionate is metabolized primarily in the liver by various cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to clobetasol propionate or any component of the formulation
- Untreated bacterial, fungal, viral (e.g., herpes simplex, varicella), or parasitic skin infections
- Acne vulgaris
- Rosacea
- Perioral dermatitis
- Pruritus without inflammation
- Perianal and genital pruritus
- Diaper rash in infants
Drug Interactions
Other Systemic Corticosteroids
Increased risk of systemic effects (e.g., HPA axis suppression) if used concomitantly.
CYP3A4 Inhibitors (e.g., Ritonavir, Itraconazole)
Clobetasol is metabolized by CYP3A4. Concomitant administration of CYP3A4 inhibitors may increase systemic exposure to clobetasol, potentially leading to increased systemic side effects. Use with caution.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with topical corticosteroids is unlikely. However, in the event of chronic overdose or misuse, symptoms of hypercorticism (e.g., Cushing's syndrome) may appear. Treatment is symptomatic and supportive. Discontinue the drug gradually under medical supervision.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether topical administration of corticosteroids can result in sufficient systemic absorption to produce detectable quantities in breast milk. Use with caution during lactation and only if the potential benefit outweighs the potential risk to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Clobetasol propionate has been extensively studied in numerous clinical trials for its efficacy and safety in various inflammatory dermatoses. Trials confirm its potent anti-inflammatory effects and rapid onset of action.
Lab Monitoring
- Not routinely required for short-term topical use.
- If large areas are treated, or with prolonged use, especially in children, monitoring for HPA axis suppression (e.g., ACTH stimulation test, plasma cortisol levels) may be considered.
Doctor Notes
- Clobetasol is a very potent corticosteroid, limit treatment duration to 2-4 weeks.
- Re-evaluate patient if no improvement seen within 2 weeks.
- Avoid use in children under 12 years unless absolutely necessary and under strict supervision due to increased risk of systemic absorption and HPA axis suppression.
- Counsel patients on proper application technique and potential side effects.
Patient Guidelines
- Use this medicine exactly as prescribed by your doctor.
- Do not use for longer than the prescribed duration (typically not more than 4 weeks).
- Avoid applying to the face, groin, or armpits unless specifically directed by your doctor.
- Do not use under occlusive dressings or tight clothing without consulting your doctor.
- Wash your hands before and after applying the cream.
- Do not get this medicine in your eyes, nose, or mouth.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not apply extra medicine to make up for a missed dose.
Driving Precautions
Topical clobetasol propionate is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Keep your skin moisturized regularly, especially after bathing.
- Avoid harsh soaps and skin irritants.
- Wear loose-fitting clothing over treated areas to prevent irritation and allow skin to breathe.
- Maintain good hygiene to prevent secondary infections.
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