Clozema
Generic Name
Clobetasol Propionate 0.05% w/w
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| clozema 005 ointment | ৳ 65.00 | N/A |
Description
Overview of the medicine
Clozema 0.05% Ointment contains Clobetasol Propionate, a highly potent corticosteroid, used for short-term treatment of inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area once or twice daily. Do not use for more than 2-4 consecutive weeks without medical review.
Elderly
Use with caution. Dosage adjustments may be necessary due to potential for increased systemic absorption and adverse effects.
Renal_impairment
No specific dosage adjustment required for topical application, but monitor for systemic effects with prolonged use on large areas.
How to Take
For external topical use only. Apply a thin film to the affected skin area and rub in gently. Wash hands after application unless hands are the treated area.
Mechanism of Action
Clobetasol propionate is a highly potent topical corticosteroid. It works by activating naturally occurring substances in the skin to reduce inflammation, itching, and redness. It binds to glucocorticoid receptors, inhibiting the release of arachidonic acid and subsequent formation of prostaglandins and leukotrienes.
Pharmacokinetics
Onset
Anti-inflammatory and antipruritic effects begin within hours of application.
Excretion
Excreted mainly in the urine, with some excretion in the bile.
Half life
Plasma half-life of absorbed clobetasol propionate is approximately 3-5 hours, though systemic effects are often minimized with proper topical use.
Absorption
Systemic absorption occurs, especially with prolonged use, large areas, occlusive dressings, or damaged skin. Absorption varies depending on the site of application and skin integrity.
Metabolism
Metabolized primarily in the liver, similar to other corticosteroids.
Side Effects
Contraindications
- Hypersensitivity to clobetasol propionate or any component
- Untreated cutaneous infections (viral, bacterial, fungal)
- Rosacea
- Acne vulgaris
- Perioral dermatitis
- Pruritus without inflammation
- Children under 1 year of age
Drug Interactions
CYP3A4 Inhibitors
May increase systemic exposure to clobetasol, leading to increased risk of systemic side effects. Examples include ritonavir and itraconazole.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is unlikely. Chronic overdose or misuse (e.g., prolonged use on large areas, under occlusion) may lead to hypercortisolism (Cushing's syndrome) and adrenal suppression. Treatment is symptomatic and supportive; gradual withdrawal of the steroid may be necessary.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Clobetasol propionate should not be used in large amounts or for prolonged periods during lactation. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Available in pharmacies and drugstores
Approval Status
Approved by health authorities
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
As a generic formulation, its efficacy and safety are based on the established clinical data of the reference product, Clobetasol Propionate. Specific trials for this brand typically focus on bioequivalence.
Lab Monitoring
- Monitor for signs of systemic corticosteroid absorption, especially with prolonged use or on large surface areas, including plasma cortisol levels if adrenal suppression is suspected.
Doctor Notes
- This is a potent corticosteroid; prescribe for short-term use only (maximum 2-4 weeks) for severe, corticosteroid-responsive dermatoses.
- Avoid use in children under 1 year. Use with caution in older children and on sensitive areas.
- Monitor for signs of systemic absorption, especially if applying to large areas or under occlusion.
Patient Guidelines
- Apply thinly and sparingly
- Do not use for longer than recommended (typically 2-4 weeks)
- Avoid use on the face, groin, or axillae unless specifically directed by a doctor
- Do not use with occlusive dressings unless advised by a doctor
- Wash hands after application.
- Avoid contact with eyes.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not apply extra ointment to make up for a missed dose.
Driving Precautions
This medicine is for topical use and is unlikely to affect your ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene
- Keep the treated area clean and dry
- Use emollients and moisturizers as advised by your doctor to keep skin hydrated.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.