Cofnil Plus
Generic Name
Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Triprolidine Hydrochloride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cofnil plus 200 mg syrup | ৳ 85.00 | N/A |
Description
Overview of the medicine
Cofnil Plus Syrup is indicated for the symptomatic relief of cough, nasal congestion, sneezing, and runny nose associated with the common cold and allergic rhinitis. It combines an antitussive (dextromethorphan), a decongestant (phenylephrine), and an antihistamine (triprolidine) to provide comprehensive relief.
Uses & Indications
Dosage
Adults
10 ml (2 teaspoonfuls) every 6 hours, not to exceed 4 doses in 24 hours.
Elderly
Use with caution. Dosage may need to be adjusted based on renal function and individual tolerance. Consult a doctor.
Renal_impairment
Use with caution. Dosage reduction may be necessary. Consult a doctor.
How to Take
Cofnil Plus Syrup is for oral administration only. It can be taken with or without food. Measure the dose accurately using a measuring spoon or cup.
Mechanism of Action
Dextromethorphan acts centrally on the cough center in the medulla to elevate the cough threshold. Phenylephrine is an alpha-adrenergic agonist that causes vasoconstriction in the nasal mucosa, reducing swelling and congestion. Triprolidine is an H1-receptor antagonist that blocks the action of histamine, thereby reducing sneezing, itching, and rhinorrhea.
Pharmacokinetics
Onset
Onset of action for decongestant and antihistamine effects is typically within 15-30 minutes. Antitussive effect starts within 15-60 minutes.
Excretion
Primarily excreted in urine as metabolites. Dextromethorphan is excreted as unchanged drug and metabolites. Phenylephrine and Triprolidine are also mainly excreted via urine.
Half life
Dextromethorphan: 1.2-3.9 hours. Phenylephrine: 2-3 hours. Triprolidine: Approximately 3-5 hours.
Absorption
Dextromethorphan and Triprolidine are well absorbed orally. Phenylephrine has variable oral absorption due to first-pass metabolism.
Metabolism
Dextromethorphan is metabolized in the liver by CYP2D6. Phenylephrine undergoes extensive first-pass metabolism in the gut wall and liver. Triprolidine is metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Dextromethorphan, Phenylephrine, Triprolidine, or any component of the formulation
- Patients currently taking or who have taken monoamine oxidase inhibitors (MAOIs) within the last 14 days
- Severe hypertension or coronary artery disease
- Narrow-angle glaucoma
- Urinary retention
- Concurrent use with other sympathomimetics or antihistamines
Drug Interactions
MAOIs
Can lead to hypertensive crisis, hyperpyrexia, and potentially fatal reactions. Avoid concurrent use and for 14 days after stopping MAOIs.
CNS Depressants
Increased sedation and CNS depression with alcohol, sedatives, tranquilizers, or other antihistamines.
Antihypertensives
Phenylephrine may reduce the efficacy of antihypertensive drugs.
CYP2D6 Inhibitors
Coadministration with inhibitors like fluoxetine, paroxetine, quinidine may increase dextromethorphan levels.
Tricyclic Antidepressants
May potentiate the effects of phenylephrine.
Storage
Store below 30°C in a cool, dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, dizziness, nausea, vomiting, rapid heart rate, hypertension, hallucinations, and seizures. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use in pregnancy and lactation only if clearly needed and the potential benefits outweigh the potential risks. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Dextromethorphan, Phenylephrine, Triprolidine, or any component of the formulation
- Patients currently taking or who have taken monoamine oxidase inhibitors (MAOIs) within the last 14 days
- Severe hypertension or coronary artery disease
- Narrow-angle glaucoma
- Urinary retention
- Concurrent use with other sympathomimetics or antihistamines
Drug Interactions
MAOIs
Can lead to hypertensive crisis, hyperpyrexia, and potentially fatal reactions. Avoid concurrent use and for 14 days after stopping MAOIs.
CNS Depressants
Increased sedation and CNS depression with alcohol, sedatives, tranquilizers, or other antihistamines.
Antihypertensives
Phenylephrine may reduce the efficacy of antihypertensive drugs.
CYP2D6 Inhibitors
Coadministration with inhibitors like fluoxetine, paroxetine, quinidine may increase dextromethorphan levels.
Tricyclic Antidepressants
May potentiate the effects of phenylephrine.
Storage
Store below 30°C in a cool, dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, dizziness, nausea, vomiting, rapid heart rate, hypertension, hallucinations, and seizures. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use in pregnancy and lactation only if clearly needed and the potential benefits outweigh the potential risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in all pharmacies
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
The active ingredients in Cofnil Plus have undergone extensive clinical trials individually and in various combinations, demonstrating efficacy and safety for their intended uses. Specific trials for this exact formulation are typically part of regulatory approval.
Lab Monitoring
- No specific laboratory monitoring is generally required for routine use.
Doctor Notes
- Advise patients on proper dose measurement, especially for pediatric use.
- Counsel patients about potential drowsiness and interactions with other CNS depressants.
- Caution against use in patients with underlying cardiovascular conditions, hypertension, or prostate hypertrophy without physician consultation.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid alcohol while taking this medicine.
- May cause drowsiness; avoid driving or operating heavy machinery.
- Consult a doctor if symptoms persist for more than 7 days or worsen.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause drowsiness, dizziness, or blurred vision. Patients should be advised not to drive or operate machinery until they know how the medicine affects them.
Lifestyle Advice
- Ensure adequate rest and hydration.
- Avoid exposure to allergens if experiencing allergic rhinitis.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.