Cofson Plus
Generic Name
Dextromethorphan Hydrobromide + Phenylephrine Hydrochloride + Chlorpheniramine Maleate Syrup
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cofson plus 100 mg syrup | ৳ 80.00 | N/A |
Description
Overview of the medicine
Cofson Plus Syrup is a combination medication used to relieve symptoms of common cold, flu, allergies, and other respiratory conditions such as sneezing, runny nose, watery eyes, cough, and nasal congestion. It contains a cough suppressant, a decongestant, and an antihistamine.
Uses & Indications
Dosage
Adults
10 mL (2 teaspoonfuls) every 6-8 hours as needed. Do not exceed 4 doses in 24 hours.
Elderly
Use with caution. Dosage may need to be adjusted by a physician.
Renal_impairment
Use with caution. Dosage adjustment may be required.
How to Take
Take orally, with or without food. Use the provided measuring cup or spoon for accurate dosing.
Mechanism of Action
Dextromethorphan suppresses cough reflex by acting on the cough center in the medulla. Phenylephrine is a sympathomimetic amine that acts as a decongestant by vasoconstriction. Chlorpheniramine Maleate is an antihistamine that blocks H1 receptors, reducing allergic symptoms like sneezing and runny nose.
Pharmacokinetics
Onset
Within 15-30 minutes for symptomatic relief.
Excretion
Mainly renal, with metabolites excreted in urine.
Half life
Dextromethorphan: Approximately 2-4 hours; Phenylephrine: 2-3 hours; Chlorpheniramine: 12-15 hours.
Absorption
Dextromethorphan is rapidly absorbed from the GI tract. Phenylephrine and Chlorpheniramine are also well absorbed orally.
Metabolism
Primarily hepatic, extensive first-pass metabolism for Phenylephrine.
Side Effects
Contraindications
- Hypersensitivity to any active ingredient or excipient.
- Patients currently taking or who have taken Monoamine Oxidase Inhibitors (MAOIs) within the last 14 days.
- Severe hypertension, severe coronary artery disease, narrow-angle glaucoma, prostatic hypertrophy.
Drug Interactions
MAOIs
Concomitant use with MAOIs can lead to hypertensive crisis.
Beta-blockers
May increase the risk of hypertension with phenylephrine.
Tricyclic Antidepressants
May potentiate the effects of decongestants.
CNS Depressants (e.g., alcohol, sedatives, hypnotics)
May enhance CNS depression, leading to increased drowsiness and sedation.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, dizziness, nausea, vomiting, rapid heartbeat, hypertension, hallucinations, and seizures. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. It is advised to consult a doctor before use during pregnancy or lactation.
Side Effects
Contraindications
- Hypersensitivity to any active ingredient or excipient.
- Patients currently taking or who have taken Monoamine Oxidase Inhibitors (MAOIs) within the last 14 days.
- Severe hypertension, severe coronary artery disease, narrow-angle glaucoma, prostatic hypertrophy.
Drug Interactions
MAOIs
Concomitant use with MAOIs can lead to hypertensive crisis.
Beta-blockers
May increase the risk of hypertension with phenylephrine.
Tricyclic Antidepressants
May potentiate the effects of decongestants.
CNS Depressants (e.g., alcohol, sedatives, hypnotics)
May enhance CNS depression, leading to increased drowsiness and sedation.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, dizziness, nausea, vomiting, rapid heartbeat, hypertension, hallucinations, and seizures. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. It is advised to consult a doctor before use during pregnancy or lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies and drugstores nationwide in Bangladesh
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Generic
Clinical Trials
The active ingredients are well-established and have undergone numerous clinical trials individually and in combination for efficacy and safety.
Lab Monitoring
- Not typically required for routine use. Blood pressure monitoring may be advisable in patients with pre-existing hypertension.
Doctor Notes
- Advise patients about potential drowsiness and to avoid alcohol.
- Exercise caution in patients with hypertension, cardiovascular disease, hyperthyroidism, diabetes mellitus, or prostatic enlargement.
- Not for self-medication in children under 6 years without physician consultation.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid concurrent use with alcohol or other CNS depressants.
- Consult a doctor if symptoms persist for more than 7 days or worsen.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Ensure adequate rest and hydration.
- Avoid environmental irritants that may worsen cough or nasal congestion.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.