Cogniz
Generic Name
Citicoline
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cogniz 500 mg tablet | ৳ 50.00 | ৳ 500.00 |
Description
Overview of the medicine
Cogniz 500 mg Tablet contains Citicoline, a brain chemical that occurs naturally in the body. It helps in the recovery of brain function and improves cognitive abilities after conditions like stroke or head injury. It also supports memory, focus, and overall brain health.
Uses & Indications
Dosage
Adults
500-1000 mg daily, administered as a single dose or divided into two doses, or as directed by the physician.
Elderly
No specific dose adjustment is required for elderly patients, but caution is advised in those with pre-existing conditions.
Renal_impairment
No specific dose adjustment required for renal impairment, as excretion is minimal via kidneys.
How to Take
Tablets should be swallowed whole with water, with or without food.
Mechanism of Action
Citicoline works by increasing the synthesis of phosphatidylcholine, a major component of neuronal membranes. It also enhances the production of several neurotransmitters, including acetylcholine, norepinephrine, and dopamine, which are crucial for brain function. This action helps to repair damaged cell membranes, reduce brain edema, and improve cerebral blood flow.
Pharmacokinetics
Onset
Clinical effects typically observed within days to weeks of consistent administration.
Excretion
Primarily excreted as CO2 via respiration (minor) and unabsorbed portion via feces (minor). Metabolites are incorporated into various metabolic pathways.
Half life
Biphasic elimination with an initial half-life of 1.5 hours and a terminal half-life of 24-72 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with bioavailability of approximately 90%.
Metabolism
Metabolized in the intestinal wall and liver into choline and cytidine.
Side Effects
Contraindications
- •Known hypersensitivity to Citicoline or any component of the formulation
- •Acute hemorrhagic stroke (controversial, consult physician)
Drug Interactions
Levodopa
May enhance the effects of Levodopa (used in Parkinson's disease).
Meclofenoxate
Concurrent use may result in additive effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
No cases of overdose have been reported with Citicoline. Symptomatic and supportive measures should be taken if an overdose is suspected.
Pregnancy & Lactation
Limited data available. Use during pregnancy and lactation is not recommended unless clearly necessary and benefits outweigh potential risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by Directorate General of Drug Administration (DGDA)
Patent Status
Patent Expired, Generic Available
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Global Brand Names
International brand names for this medicine
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