Colik
Generic Name
Dicyclomine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| colik 20 mg tablet | ৳ 6.72 | ৳ 67.20 |
Description
Overview of the medicine
Colik 20 mg tablet contains Dicyclomine Hydrochloride, an antispasmodic medication used to treat symptoms of irritable bowel syndrome (IBS) such as cramps, pain, and bloating. It works by relaxing the smooth muscles of the stomach and intestine.
Uses & Indications
Dosage
Adults
Oral: Initially 20 mg three or four times daily; may increase to 40 mg three or four times daily if needed. Maximum 160 mg/day.
Elderly
Start with lower doses (e.g., 10 mg three times daily) and titrate carefully based on response and tolerability, due to increased susceptibility to anticholinergic effects.
Renal_impairment
Use with caution. Dose reduction may be necessary in severe renal impairment.
How to Take
Take the tablet orally with or without food. It can be taken before or after meals.
Mechanism of Action
Dicyclomine is an anticholinergic (antimuscarinic) agent that blocks the action of acetylcholine at muscarinic receptors on smooth muscle, thereby reducing muscle spasms and contractions in the gastrointestinal tract and diminishing secretory activity.
Pharmacokinetics
Onset
1-2 hours
Excretion
Excreted primarily in urine (approximately 79.5%) and feces (approximately 8.4%).
Half life
1.8 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached within 1-1.5 hours.
Metabolism
Metabolized primarily in the liver.
Side Effects
Contraindications
- Hypersensitivity to dicyclomine or any component
- Obstructive uropathy
- Obstructive disease of the gastrointestinal tract (e.g., achalasia, pyloroduodenal stenosis)
- Severe ulcerative colitis or toxic megacolon
- Reflux esophagitis
- Unstable cardiovascular status in acute hemorrhage
- Glaucoma
- Myasthenia gravis
- Infants less than 6 months of age
- Lactating mothers
Drug Interactions
Digoxin
May increase serum digoxin levels due to delayed gastric emptying. Monitor digoxin levels.
Antacids
May interfere with the absorption of dicyclomine; administer dicyclomine before meals and antacids after meals.
Metoclopramide, Cisapride
Antagonistic effects on GI motility.
Other anticholinergics (e.g., tricyclic antidepressants, phenothiazines)
May potentiate the anticholinergic effects (e.g., dry mouth, blurred vision, constipation).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dry mouth, blurred vision, pupil dilation, tachycardia, urinary retention, headache, dizziness, nausea, vomiting, and CNS stimulation (e.g., restlessness, excitement, confusion, psychosis). Severe overdose may lead to coma, respiratory depression, and circulatory collapse. Management is supportive, and physostigmine may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Dicyclomine is excreted in breast milk and may cause adverse effects in nursing infants; therefore, it is contraindicated in lactating mothers.
Side Effects
Contraindications
- Hypersensitivity to dicyclomine or any component
- Obstructive uropathy
- Obstructive disease of the gastrointestinal tract (e.g., achalasia, pyloroduodenal stenosis)
- Severe ulcerative colitis or toxic megacolon
- Reflux esophagitis
- Unstable cardiovascular status in acute hemorrhage
- Glaucoma
- Myasthenia gravis
- Infants less than 6 months of age
- Lactating mothers
Drug Interactions
Digoxin
May increase serum digoxin levels due to delayed gastric emptying. Monitor digoxin levels.
Antacids
May interfere with the absorption of dicyclomine; administer dicyclomine before meals and antacids after meals.
Metoclopramide, Cisapride
Antagonistic effects on GI motility.
Other anticholinergics (e.g., tricyclic antidepressants, phenothiazines)
May potentiate the anticholinergic effects (e.g., dry mouth, blurred vision, constipation).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dry mouth, blurred vision, pupil dilation, tachycardia, urinary retention, headache, dizziness, nausea, vomiting, and CNS stimulation (e.g., restlessness, excitement, confusion, psychosis). Severe overdose may lead to coma, respiratory depression, and circulatory collapse. Management is supportive, and physostigmine may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Dicyclomine is excreted in breast milk and may cause adverse effects in nursing infants; therefore, it is contraindicated in lactating mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Dicyclomine has been extensively studied in clinical trials for the symptomatic relief of Irritable Bowel Syndrome (IBS), demonstrating its efficacy in reducing abdominal pain and cramps compared to placebo.
Lab Monitoring
- No specific routine laboratory monitoring is required for dicyclomine.
Doctor Notes
- Caution in patients with benign prostatic hyperplasia due to risk of urinary retention.
- Monitor elderly patients carefully for CNS anticholinergic effects like confusion or delirium.
- Avoid in infants due to serious adverse events including respiratory depression and seizures.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid alcohol while taking this medication as it may increase drowsiness.
- If you experience dizziness or blurred vision, avoid driving or operating machinery.
- Inform your doctor if your symptoms worsen or if new symptoms appear.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness, drowsiness, or blurred vision. Do not drive or operate heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Manage stress effectively as it can exacerbate IBS symptoms.
- Identify and avoid trigger foods that worsen your bowel symptoms.
- Maintain a balanced diet and adequate fluid intake.
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