Combat
Generic Name
Paracetamol (Acetaminophen) + Caffeine
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| combat 02 05 eye drop | ৳ 120.00 | N/A |
Description
Overview of the medicine
Combat tablet is a combination of Paracetamol and Caffeine. It is used for fast and effective relief from various types of pain and fever.
Uses & Indications
Dosage
Adults
1-2 tablets every 4-6 hours, not exceeding 8 tablets in 24 hours.
Elderly
Same as adult dose, but caution advised for liver/kidney impairment.
Renal_impairment
Dosage adjustment may be necessary; consult a physician.
How to Take
Take orally with water, with or without food.
Mechanism of Action
Paracetamol works by inhibiting prostaglandin synthesis in the central nervous system, thereby providing analgesic and antipyretic effects. Caffeine acts as a CNS stimulant, enhancing the analgesic effect of paracetamol and reducing fatigue.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Mainly excreted in urine as metabolites.
Half life
Paracetamol: 1-3 hours; Caffeine: 3-7 hours
Absorption
Paracetamol is rapidly and completely absorbed from the GI tract. Caffeine is also rapidly absorbed.
Metabolism
Paracetamol is primarily metabolized in the liver. Caffeine is extensively metabolized by the liver.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or caffeine
- Severe liver disease
- Severe renal impairment
- G6PD deficiency
Drug Interactions
Alcohol
Increased risk of liver damage with paracetamol.
Warfarin
May enhance anticoagulant effect of warfarin with prolonged use.
Certain antidepressants
Increased risk of caffeine side effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose can cause severe liver damage (paracetamol) and symptoms like palpitation, insomnia, anxiety (caffeine). Seek immediate medical attention.
Pregnancy & Lactation
Generally considered safe at recommended doses, but consult a doctor. Caffeine intake should be limited during pregnancy and lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous trials support the efficacy and safety of paracetamol-caffeine combinations for pain and fever.
Lab Monitoring
- Liver function tests (in prolonged high dose use)
- Renal function tests (in patients with impairment)
Doctor Notes
- Advise patients not to exceed 4g/day of paracetamol from all sources.
- Counsel on potential for caffeine-related side effects, especially with other caffeine intake.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking other paracetamol-containing products simultaneously.
- Consult a doctor if symptoms persist for more than 3 days (fever) or 5 days (pain).
Missed Dose Advice
If a dose is missed, take it as soon as you remember. Do not double the dose.
Driving Precautions
Generally safe. May cause dizziness in some individuals, caution advised.
Lifestyle Advice
- Ensure adequate rest and hydration.
- Limit caffeine intake from other sources while taking this medication.
- Avoid alcohol.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.