Combivit
Generic Name
Thiamine Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Nicotinamide, Calcium Pantothenate, Cyanocobalamin, Ascorbic Acid, Folic Acid
Manufacturer
Various manufacturers (e.g., Square Pharmaceuticals Ltd.)
Country
Bangladesh
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Description
Overview of the medicine
Combivit is a nutritional supplement combining essential B-complex vitamins and Vitamin C. It is used to prevent or treat vitamin deficiencies, support overall health, and boost immunity.
Uses & Indications
Dosage
Adults
Usually 1-2 tablets/capsules daily, or 5-10 ml syrup 1-2 times daily, or as directed by physician.
Elderly
Same as adult dosage, or as advised by physician.
Renal_impairment
Generally safe in standard doses; consult physician for severe impairment.
How to Take
Oral forms can be taken with or without food. Injections are administered intramuscularly or intravenously by a healthcare professional.
Mechanism of Action
B-complex vitamins act as coenzymes in various metabolic processes, including energy production and cell function. Vitamin C is an antioxidant essential for collagen synthesis, immune function, and iron absorption.
Pharmacokinetics
Onset
Effects on nutritional status are gradual, over days to weeks.
Excretion
Mainly excreted unchanged or as metabolites in urine.
Half life
Short, typically hours for most water-soluble vitamins, requiring regular intake.
Absorption
Water-soluble vitamins are readily absorbed from the gastrointestinal tract.
Metabolism
Minimal metabolism for most, primarily utilized as coenzymes.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation
- Severe renal impairment (for some components or high doses)
Drug Interactions
Levodopa
Pyridoxine (Vitamin B6) may reduce the efficacy of levodopa (used in Parkinson's disease).
Certain antibiotics (e.g., Tetracyclines)
Some vitamins might affect absorption.
Folic acid antagonists (e.g., Methotrexate)
Folic acid may interfere with the action of these drugs.
Storage
Store in a cool, dry place, below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose with water-soluble vitamins is rare due to their rapid excretion. Symptoms of extremely high doses might include mild gastrointestinal upset. Treatment is supportive.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation to meet increased nutritional demands, but consult a healthcare professional before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies and drugstores
Approval Status
Generally approved as OTC supplement
Patent Status
Off-patent (individual vitamins)
Clinical Trials
Individual components (vitamins) have been extensively studied. Clinical trials specific to 'Combivit' as a brand would focus on its formulation's bioavailability and efficacy in specific populations, often showing effectiveness in treating or preventing vitamin deficiencies.
Lab Monitoring
- No routine lab monitoring required for typical usage. May be monitored for specific vitamin deficiency states.
Doctor Notes
- Advise patients on the importance of a balanced diet alongside supplementation.
- Counsel on potential interactions with levodopa if the patient is on Parkinson's medication.
- Reassure patients about harmless urine discoloration due to riboflavin.
Patient Guidelines
- Take as directed by your physician or as indicated on the package.
- Do not exceed the recommended dose.
- Maintain a balanced diet in addition to taking supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose.
Driving Precautions
Combivit is not known to impair the ability to drive or operate machinery.
Lifestyle Advice
- Incorporate a healthy and balanced diet rich in fruits, vegetables, and whole grains.
- Maintain adequate hydration.
- Engage in regular physical activity.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.