Combofresh
Generic Name
Chlorhexidine Gluconate + Sodium Fluoride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| combofresh 02 036 eye drop | ৳ 275.00 | N/A |
Description
Overview of the medicine
Combofresh is an antiseptic and anti-caries mouthwash used for comprehensive oral hygiene. It helps to reduce plaque, prevent gingivitis, and protect against tooth decay.
Uses & Indications
Dosage
Adults
Rinse mouth with 10-15 ml (undiluted) for 30-60 seconds, twice daily, after brushing. Do not swallow.
Elderly
No specific dose adjustment required for elderly; use as adult dosage.
Renal_impairment
No specific dose adjustment required; minimal systemic absorption.
How to Take
For oral use only. Swish the mouthwash around the mouth and then spit out. Do not rinse with water immediately after use. Avoid eating or drinking for 30 minutes after use.
Mechanism of Action
Chlorhexidine disrupts bacterial cell membranes, inhibiting their growth and adhesion. Sodium fluoride strengthens tooth enamel by promoting remineralization, making teeth more resistant to acid attacks.
Pharmacokinetics
Onset
Immediate antiseptic action on contact; fluoride's anti-caries effect develops over time with regular use.
Excretion
Primarily expelled orally; any minimally absorbed component is excreted via urine and feces.
Half life
Chlorhexidine: remains in oral cavity for up to 12 hours due to substantivity. Fluoride: not significantly absorbed systemically.
Absorption
Minimal systemic absorption through oral mucosa; primarily acts topically.
Metabolism
Minimal systemic metabolism due to poor absorption.
Side Effects
Contraindications
- Hypersensitivity to Chlorhexidine, Fluoride, or any other ingredients
- Children under 6 years of age (due to swallowing risk)
Drug Interactions
Anionic agents
May inactivate chlorhexidine. Use at least 30 minutes apart from conventional toothpastes containing sodium lauryl sulfate.
Other fluoride products
Concurrent use may lead to excessive fluoride intake, though rare with topical products.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Accidental ingestion of large quantities may cause gastrointestinal upset (nausea, vomiting, diarrhea). In such cases, drink milk or water and seek medical advice. Fluoride overdose is rare with mouthwashes but can cause fluorosis with chronic excessive ingestion.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation when used as directed, as systemic absorption is minimal. Consult a healthcare professional if concerned.
Side Effects
Contraindications
- Hypersensitivity to Chlorhexidine, Fluoride, or any other ingredients
- Children under 6 years of age (due to swallowing risk)
Drug Interactions
Anionic agents
May inactivate chlorhexidine. Use at least 30 minutes apart from conventional toothpastes containing sodium lauryl sulfate.
Other fluoride products
Concurrent use may lead to excessive fluoride intake, though rare with topical products.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Accidental ingestion of large quantities may cause gastrointestinal upset (nausea, vomiting, diarrhea). In such cases, drink milk or water and seek medical advice. Fluoride overdose is rare with mouthwashes but can cause fluorosis with chronic excessive ingestion.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation when used as directed, as systemic absorption is minimal. Consult a healthcare professional if concerned.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, Superstores, Online
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Information on clinical trials for this specific brand may not be publicly available for OTC products, but ingredients are well-established.
Lab Monitoring
- None routinely required for topical use.
Doctor Notes
- Advise patients on proper rinsing technique and to avoid swallowing.
- Emphasize that it's an adjunct to, not a replacement for, brushing and flossing.
- Monitor for staining and taste changes.
Patient Guidelines
- Do not swallow the mouthwash.
- Do not dilute the mouthwash unless instructed.
- Avoid using toothpaste containing sodium lauryl sulfate immediately before or after.
- Brush teeth thoroughly before using the mouthwash.
Missed Dose Advice
If a dose is missed, continue with the next scheduled dose. Do not use extra mouthwash to make up for a missed dose.
Driving Precautions
No known effects on ability to drive or operate machinery.
Lifestyle Advice
- Maintain good oral hygiene practices including regular brushing and flossing.
- Limit sugary foods and drinks.
- Regular dental check-ups.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Combofresh Brand
Other medicines available under the same brand name
