Conate-D
Generic Name
Calcium Carbonate + Cholecalciferol (Vitamin D3)
Manufacturer
General Pharmaceuticals Ltd. (Example)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| conate d 500 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Conate-D 500 mg Tablet is a combination supplement containing elemental calcium and Vitamin D3. It is used to prevent and treat calcium and Vitamin D deficiencies, promoting bone health and strength.
Uses & Indications
Dosage
Adults
Typically 1-2 tablets daily, or as directed by a physician. May be taken with or without food, but taking with food may improve absorption.
Elderly
Similar to adult dosage; however, renal function should be considered, and dosage may be adjusted by a physician.
Renal_impairment
Use with caution. Dosage adjustments may be necessary, and calcium and phosphate levels should be monitored. Consult a physician.
How to Take
For oral administration. The tablet can be swallowed whole with water. Taking it with meals may enhance absorption, especially of Vitamin D.
Mechanism of Action
Calcium is an essential mineral required for bone formation, muscle contraction, nerve function, and blood coagulation. Vitamin D3 facilitates the absorption of calcium from the gastrointestinal tract and helps maintain calcium and phosphate homeostasis in the body.
Pharmacokinetics
Onset
Effects on bone mineral density are gradual, over weeks to months.
Excretion
Calcium is excreted via urine and feces. Vitamin D3 metabolites are primarily excreted via bile and feces.
Half life
Vitamin D3 metabolites (e.g., calcifediol) have a half-life of several weeks. Calcium's half-life is complex due to its constant turnover in bone.
Absorption
Calcium absorption is primarily in the small intestine, enhanced by Vitamin D3. Vitamin D3 is absorbed from the small intestine and is fat-soluble.
Metabolism
Vitamin D3 is hydroxylated in the liver to calcifediol (25-hydroxyvitamin D3) and then in the kidneys to calcitriol (1,25-dihydroxyvitamin D3), the active form. Calcium is largely incorporated into bone or excreted.
Side Effects
Contraindications
- Hypersensitivity to the active substances or to any of the excipients
- Hypercalcemia (high levels of calcium in blood)
- Severe hypercalciuria (high levels of calcium in urine)
- Nephrolithiasis (kidney stones)
- Severe renal impairment
- Primary hyperparathyroidism
Drug Interactions
Digoxin
Hypercalcemia from vitamin D may increase the risk of digoxin toxicity.
Levothyroxine
Absorption may be decreased. Separate doses by at least 4 hours.
Bisphosphonates
Calcium can interfere with the absorption of bisphosphonates. Should be taken at least 30 minutes apart.
Corticosteroids
Can reduce calcium absorption.
Thiazide diuretics
May reduce urinary excretion of calcium, increasing the risk of hypercalcemia.
Tetracyclines and Fluoroquinolones
Calcium can impair the absorption of these antibiotics. Should be administered at least 2-3 hours apart.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypercalcemia) include nausea, vomiting, constipation, polyuria, polydipsia, muscle weakness, confusion, fatigue, and in severe cases, cardiac arrhythmias and kidney stones. Management involves discontinuing the supplement, ensuring adequate hydration, and seeking immediate medical attention.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation for adequate calcium and Vitamin D intake, but only under medical supervision and within recommended doses. Excessive intake may be harmful.
Side Effects
Contraindications
- Hypersensitivity to the active substances or to any of the excipients
- Hypercalcemia (high levels of calcium in blood)
- Severe hypercalciuria (high levels of calcium in urine)
- Nephrolithiasis (kidney stones)
- Severe renal impairment
- Primary hyperparathyroidism
Drug Interactions
Digoxin
Hypercalcemia from vitamin D may increase the risk of digoxin toxicity.
Levothyroxine
Absorption may be decreased. Separate doses by at least 4 hours.
Bisphosphonates
Calcium can interfere with the absorption of bisphosphonates. Should be taken at least 30 minutes apart.
Corticosteroids
Can reduce calcium absorption.
Thiazide diuretics
May reduce urinary excretion of calcium, increasing the risk of hypercalcemia.
Tetracyclines and Fluoroquinolones
Calcium can impair the absorption of these antibiotics. Should be administered at least 2-3 hours apart.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypercalcemia) include nausea, vomiting, constipation, polyuria, polydipsia, muscle weakness, confusion, fatigue, and in severe cases, cardiac arrhythmias and kidney stones. Management involves discontinuing the supplement, ensuring adequate hydration, and seeking immediate medical attention.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation for adequate calcium and Vitamin D intake, but only under medical supervision and within recommended doses. Excessive intake may be harmful.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Superstores, Online
Approval Status
Approved (Generally available as a supplement)
Patent Status
Off-patent / Generic
Clinical Trials
Numerous clinical trials support the efficacy of calcium and Vitamin D supplementation in improving bone mineral density and reducing fracture risk, particularly in specific populations such as postmenopausal women and the elderly.
Lab Monitoring
- Serum calcium levels (especially in patients with renal impairment or on long-term therapy)
- Serum phosphate levels
- Renal function (creatinine, GFR)
Doctor Notes
- Conate-D is a valuable supplement for addressing calcium and Vitamin D deficiencies, crucial for maintaining skeletal health.
- Always assess patient's dietary intake and other medications to avoid potential interactions or excessive dosing.
- Monitor serum calcium levels periodically in at-risk patients (e.g., renal impairment, long-term use, concomitant medications).
Patient Guidelines
- Take as directed by your doctor or pharmacist. Do not exceed the recommended dose.
- Inform your doctor about all other medications and supplements you are taking.
- Maintain a balanced diet rich in calcium and vitamin D.
- Report any unusual side effects to your healthcare provider.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Conate-D 500 mg Tablet is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Engage in regular weight-bearing exercises to support bone health.
- Ensure adequate sun exposure for natural Vitamin D synthesis, while practicing sun safety.
- Avoid smoking and excessive alcohol consumption, which can negatively impact bone density.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.