conrif-ds
Generic Name
Cyclosporine Ophthalmic Emulsion
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| conrif ds 02 eye drop | ৳ 150.00 | N/A |
Description
Overview of the medicine
Conrif-DS eye drop is an ophthalmic emulsion containing Cyclosporine, primarily used to increase natural tear production in patients with chronic dry eye disease.
Uses & Indications
Dosage
Adults
Instill one drop in each affected eye twice daily, approximately 12 hours apart.
Elderly
No dosage adjustment is necessary for elderly patients.
Renal_impairment
No dosage adjustment is necessary due to minimal systemic absorption.
How to Take
For ophthalmic use only. Invert the closed unit dose vial a few times to obtain a uniform, opaque, white emulsion before use. Do not touch the dropper tip to any surface. Remove contact lenses prior to administration and wait 15 minutes before reinserting them.
Mechanism of Action
Cyclosporine acts as a calcineurin inhibitor, suppressing immune responses and reducing inflammation associated with chronic dry eye disease, thereby increasing natural tear production.
Pharmacokinetics
Onset
Clinical improvement in tear production may take several weeks to months.
Excretion
Mainly local excretion; minimal systemic excretion.
Half life
Systemic half-life is not clinically significant for ophthalmic use.
Absorption
Minimal systemic absorption following topical ophthalmic administration.
Metabolism
Primarily metabolized in ocular tissues; minimal systemic metabolism.
Side Effects
Contraindications
- Hypersensitivity to cyclosporine or any of the other ingredients.
Drug Interactions
Other topical ophthalmic medications
If using more than one topical ophthalmic medication, administer them at least 15 minutes apart.
Storage
Store at room temperature (below 25°C), protect from light. Do not freeze. Keep out of reach of children.
Overdose
Topical ophthalmic overdose is unlikely to cause systemic toxicity. If accidentally ingested, supportive measures may be necessary.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing woman due to minimal systemic absorption; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to cyclosporine or any of the other ingredients.
Drug Interactions
Other topical ophthalmic medications
If using more than one topical ophthalmic medication, administer them at least 15 minutes apart.
Storage
Store at room temperature (below 25°C), protect from light. Do not freeze. Keep out of reach of children.
Overdose
Topical ophthalmic overdose is unlikely to cause systemic toxicity. If accidentally ingested, supportive measures may be necessary.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing woman due to minimal systemic absorption; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
18-24 months from manufacturing date, check specific packaging for details.
Availability
Pharmacies, hospitals, and clinics nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Cyclosporine ophthalmic emulsions have undergone extensive clinical trials demonstrating efficacy and safety for chronic dry eye disease.
Lab Monitoring
- No specific laboratory monitoring is typically required for ophthalmic cyclosporine use.
Doctor Notes
- Emphasize the importance of consistent daily use for optimal therapeutic outcomes.
- Advise patients that onset of action may not be immediate and sustained use is necessary.
- Monitor for signs of ocular infection or irritation.
Patient Guidelines
- Do not let the tip of the dropper touch your eye or any other surface.
- Remove contact lenses before use and wait at least 15 minutes before reinserting them.
- Use consistently for the prescribed duration to achieve full therapeutic effect.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause temporary blurred vision. Patients should be cautious when driving or operating machinery until vision clears.
Lifestyle Advice
- Maintain good ocular hygiene to prevent infections.
- Avoid environmental irritants that can worsen dry eye symptoms.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.