Coral Calcium D
Generic Name
Coral Calcium & Vitamin D3 Tablet
Manufacturer
Generic Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| coral calcium d 500 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Coral Calcium D 500 mg Tablet is a nutritional supplement combining elemental calcium derived from coral sources with Vitamin D3. It is used to prevent and treat calcium and vitamin D deficiencies, support bone health, and maintain proper mineral balance in the body. Coral calcium is known for its high bioavailability and alkaline properties.
Uses & Indications
Dosage
Adults
Typically, 1-2 tablets daily, or as directed by a physician. Should be taken with food for better absorption.
Elderly
Same as adult dosage, but caution with pre-existing renal impairment or hypercalcemia risk.
Renal_impairment
Use with caution and dose adjustment may be necessary. Regular monitoring of calcium and phosphate levels is recommended. Not recommended in severe renal impairment without medical supervision.
How to Take
Oral administration. Tablets should be swallowed whole with water, preferably with food to maximize absorption and reduce gastrointestinal upset. Do not exceed the recommended dose.
Mechanism of Action
Coral Calcium provides elemental calcium which is essential for bone formation, muscle contraction, nerve function, and blood clotting. Vitamin D3 (Cholecalciferol) facilitates the absorption of calcium from the intestine and regulates calcium and phosphate homeostasis in the body, promoting bone mineralization.
Pharmacokinetics
Onset
Calcium levels begin to rise within hours of administration; bone mineralization effects are gradual over weeks to months.
Excretion
Calcium: Primarily via kidneys (urine) and intestines (feces). Vitamin D3: Metabolites excreted primarily in bile and feces, with a smaller amount in urine.
Half life
Calcium: Varies significantly, several hours to days depending on physiological state. Vitamin D3: Elimination half-life of 24-48 hours, but active metabolite (calcitriol) has a half-life of about 15 hours. Storage in fat cells can prolong effects.
Absorption
Calcium from coral calcium is absorbed mainly in the small intestine via active transport and passive diffusion, with absorption enhanced by Vitamin D. Vitamin D3 is absorbed from the small intestine, primarily in the jejunum, and transported via chylomicrons.
Metabolism
Calcium is not metabolized in the traditional sense, but constantly exchanged with bone. Vitamin D3 is hydroxylated in the liver to 25-hydroxyvitamin D [25(OH)D] (calcidiol), then in the kidneys to 1,25-dihydroxyvitamin D [1,25(OH)2D] (calcitriol), the active form.
Side Effects
Contraindications
- Hypersensitivity to any component
- Hypercalcemia (abnormally high levels of calcium in the blood)
- Hypercalciuria (abnormally high levels of calcium in the urine)
- Severe renal impairment
- Known hyperparathyroidism or other conditions leading to hypercalcemia
Drug Interactions
Levothyroxine
Calcium can reduce levothyroxine absorption. Separate administration by at least 4 hours.
Bisphosphonates
Calcium can interfere with the absorption of bisphosphonates. Administer calcium at least 30 minutes after bisphosphonates.
Corticosteroids
Can reduce calcium absorption and increase calcium excretion.
Thiazide Diuretics
May increase the risk of hypercalcemia by decreasing urinary calcium excretion.
Cardiac Glycosides (e.g., Digoxin)
Hypercalcemia may potentiate the effects of cardiac glycosides, increasing the risk of arrhythmias. Monitor carefully.
Tetracycline and Fluoroquinolone Antibiotics
Calcium can bind to these antibiotics, reducing their absorption. Take calcium at least 2 hours before or 4-6 hours after these antibiotics.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia, nausea, vomiting, constipation, polyuria, polydipsia, and fatigue. In severe cases, cardiac arrhythmias and coma may occur. Management involves discontinuation of the supplement, hydration, and medical support. In chronic cases, renal dysfunction and soft tissue calcification may develop.
Pregnancy & Lactation
Considered safe and often recommended during pregnancy and lactation to meet increased calcium and Vitamin D requirements. Consult a physician for appropriate dosage.
Side Effects
Contraindications
- Hypersensitivity to any component
- Hypercalcemia (abnormally high levels of calcium in the blood)
- Hypercalciuria (abnormally high levels of calcium in the urine)
- Severe renal impairment
- Known hyperparathyroidism or other conditions leading to hypercalcemia
Drug Interactions
Levothyroxine
Calcium can reduce levothyroxine absorption. Separate administration by at least 4 hours.
Bisphosphonates
Calcium can interfere with the absorption of bisphosphonates. Administer calcium at least 30 minutes after bisphosphonates.
Corticosteroids
Can reduce calcium absorption and increase calcium excretion.
Thiazide Diuretics
May increase the risk of hypercalcemia by decreasing urinary calcium excretion.
Cardiac Glycosides (e.g., Digoxin)
Hypercalcemia may potentiate the effects of cardiac glycosides, increasing the risk of arrhythmias. Monitor carefully.
Tetracycline and Fluoroquinolone Antibiotics
Calcium can bind to these antibiotics, reducing their absorption. Take calcium at least 2 hours before or 4-6 hours after these antibiotics.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia, nausea, vomiting, constipation, polyuria, polydipsia, and fatigue. In severe cases, cardiac arrhythmias and coma may occur. Management involves discontinuation of the supplement, hydration, and medical support. In chronic cases, renal dysfunction and soft tissue calcification may develop.
Pregnancy & Lactation
Considered safe and often recommended during pregnancy and lactation to meet increased calcium and Vitamin D requirements. Consult a physician for appropriate dosage.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Pharmacies, drugstores, supermarkets, online stores
Approval Status
Generally Recognized As Safe (GRAS) for its components; specific brand approval by local authorities.
Patent Status
Generic; components are off-patent.
Clinical Trials
Numerous clinical trials support the efficacy of calcium and Vitamin D supplementation for bone health and deficiency prevention. Specific trials for 'Coral Calcium D' as a distinct entity might be limited, but its components are well-studied.
Lab Monitoring
- Serum Calcium levels (especially in patients with renal impairment or on prolonged high doses)
- Serum Phosphate levels
- 25(OH)D (Vitamin D) levels (to assess deficiency and treatment efficacy)
- Renal function tests (e.g., creatinine, BUN) in patients with kidney issues
- Urinary calcium excretion (if hypercalciuria is suspected)
Doctor Notes
- Advise patients to maintain adequate hydration to prevent kidney stone formation.
- Counsel on potential interactions with other medications, especially thyroid hormones and certain antibiotics.
- Emphasize that while OTC, excessive use without medical guidance can lead to adverse effects.
Patient Guidelines
- Take as directed by your doctor or pharmacist.
- Do not exceed the recommended daily dose.
- Take with food to improve absorption and reduce stomach upset.
- Inform your doctor about all other medications you are taking, especially antibiotics, thyroid hormones, or diuretics.
- Report any unusual or severe side effects to your healthcare provider.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Coral Calcium D 500 mg Tablet is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and Vitamin D.
- Engage in regular weight-bearing exercise to support bone health.
- Ensure adequate sun exposure for natural Vitamin D synthesis, while practicing sun safety.
- Avoid excessive consumption of alcohol and caffeine.
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