Adults

Dosage varies significantly based on the type of parasitic infection. For most intestinal worm infections, a single dose of 400 mg is common. For systemic infections like neurocysticercosis or hydatid disease, the dosage can be 400 mg twice daily for varying durations (e.g., 8-30 days), or as directed by a physician. A 600 mg tablet may be used for specific regimens or severe cases as determined by a specialist.

Elderly

No specific dose adjustment is generally required for elderly patients, but caution should be exercised due to potential age-related decrease in organ function.

Renal_impairment

No dose adjustment is generally required in renal impairment, as albendazole and its primary metabolite are minimally excreted by the kidneys. However, caution is advised.

Onset

Onset of anthelmintic action varies depending on the parasite and location; clinical resolution may take days to weeks.

Excretion

Primarily excreted in the urine as metabolites, with a small amount excreted in bile.

Half life

Albendazole sulfoxide (active metabolite): 8-12 hours.

Absorption

Poorly absorbed orally (<5%). Absorption is enhanced with fatty meals. Rapidly and extensively metabolized in the liver to albendazole sulfoxide, which is the primary active metabolite.

Metabolism

Extensively metabolized in the liver via first-pass metabolism to its primary active metabolite, albendazole sulfoxide, which is then further metabolized.

Theophylline

Albendazole may decrease the plasma concentrations of Theophylline, requiring monitoring of theophylline levels.

Cimetidine, Dexamethasone, Praziquantel

Cimetidine, Dexamethasone, and Praziquantel may increase the plasma concentrations of albendazole sulfoxide, potentially increasing side effects.