Corast-D
Generic Name
Calcium Carbonate (Elemental Calcium 500 mg) + Vitamin D3
Manufacturer
Generic Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| corast d 500 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Corast-D 500 mg Tablet is a nutritional supplement containing Calcium Carbonate and Vitamin D3, primarily used to prevent and treat calcium and vitamin D deficiencies. It helps maintain bone health, supports normal muscle and nerve function, and enhances calcium absorption.
Uses & Indications
Dosage
Adults
Typically 1-2 tablets daily, or as directed by physician.
Elderly
Same as adult dosage, but caution with renal impairment. May require monitoring of calcium levels.
Renal_impairment
Use with caution. Dosage adjustment may be necessary. Regular monitoring of serum calcium and phosphate levels is crucial.
How to Take
Take the tablet orally with water, preferably after meals for better absorption and to minimize gastrointestinal discomfort. Do not crush or chew the tablet unless advised by a doctor.
Mechanism of Action
Calcium Carbonate provides elemental calcium, which is essential for bone formation, maintenance, and various physiological functions like muscle contraction and nerve transmission. Vitamin D3 (Cholecalciferol) is crucial for the absorption of calcium from the gut and its incorporation into bones, regulating calcium and phosphate homeostasis.
Pharmacokinetics
Onset
Effects on calcium levels typically manifest within hours for initial absorption; long-term bone health benefits accrue over weeks to months.
Excretion
Calcium is primarily excreted via kidneys (urine) and feces. Vitamin D metabolites are primarily excreted in bile and feces, with some renal excretion.
Half life
Elemental calcium has no specific half-life; plasma calcium is tightly regulated. Vitamin D3 has a half-life of about 24 hours, while its active metabolite (calcitriol) has a half-life of 4-6 hours.
Absorption
Calcium absorption primarily occurs in the small intestine, influenced by Vitamin D. Vitamin D3 is absorbed from the gut, metabolized in the liver to 25-hydroxyvitamin D3, then in the kidneys to the active form, 1,25-dihydroxyvitamin D3.
Metabolism
Calcium is not metabolized. Vitamin D3 is hydroxylated in the liver to 25-hydroxyvitamin D3 (calcifediol) and then in the kidneys to 1,25-dihydroxyvitamin D3 (calcitriol).
Side Effects
Contraindications
- Hypersensitivity to Calcium Carbonate, Vitamin D3, or any component of the formulation
- Hypercalcemia (high levels of calcium in the blood)
- Severe hypercalciuria (excessive calcium in urine)
- Nephrolithiasis (kidney stones) or history of kidney stones
- Hypervitaminosis D
Drug Interactions
Levothyroxine
Calcium can impair absorption. Separate doses by at least 4 hours.
Bisphosphonates
Calcium can reduce their absorption. Take calcium at a different time.
Corticosteroids
May decrease calcium absorption.
Thiazide diuretics
May increase the risk of hypercalcemia.
Tetracycline and Fluoroquinolone antibiotics
Calcium can reduce their absorption. Take at least 2-3 hours before or 4-6 hours after.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia (nausea, vomiting, constipation, thirst, polyuria, muscle weakness, confusion) and hypervitaminosis D. Treatment involves discontinuing the supplement, hydration, and medical management of hypercalcemia.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation to meet increased calcium and vitamin D requirements, but use under medical supervision. Excessive doses should be avoided.
Side Effects
Contraindications
- Hypersensitivity to Calcium Carbonate, Vitamin D3, or any component of the formulation
- Hypercalcemia (high levels of calcium in the blood)
- Severe hypercalciuria (excessive calcium in urine)
- Nephrolithiasis (kidney stones) or history of kidney stones
- Hypervitaminosis D
Drug Interactions
Levothyroxine
Calcium can impair absorption. Separate doses by at least 4 hours.
Bisphosphonates
Calcium can reduce their absorption. Take calcium at a different time.
Corticosteroids
May decrease calcium absorption.
Thiazide diuretics
May increase the risk of hypercalcemia.
Tetracycline and Fluoroquinolone antibiotics
Calcium can reduce their absorption. Take at least 2-3 hours before or 4-6 hours after.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypercalcemia (nausea, vomiting, constipation, thirst, polyuria, muscle weakness, confusion) and hypervitaminosis D. Treatment involves discontinuing the supplement, hydration, and medical management of hypercalcemia.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation to meet increased calcium and vitamin D requirements, but use under medical supervision. Excessive doses should be avoided.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on storage conditions.
Availability
Available in pharmacies and drugstores
Approval Status
Approved by DGDA/FDA equivalent
Patent Status
Off-patent
Clinical Trials
Extensive clinical data support the efficacy and safety of calcium and vitamin D supplementation for bone health and deficiency states.
Lab Monitoring
- Serum calcium levels (especially in patients with renal impairment or long-term use)
- 24-hour urinary calcium excretion
- Serum phosphate levels
- Serum 25-hydroxyvitamin D levels (occasionally)
Doctor Notes
- Advise patients on dietary sources of calcium and vitamin D.
- Monitor serum calcium and renal function in patients at risk of hypercalcemia or renal impairment.
- Educate patients on potential drug interactions, especially with antibiotics and thyroid hormones.
Patient Guidelines
- Take as directed, preferably with meals.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications and supplements you are taking.
- Maintain adequate fluid intake.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Corast-D 500 mg Tablet is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Ensure a balanced diet rich in calcium and vitamin D.
- Engage in weight-bearing exercises to promote bone health.
- Get adequate sunlight exposure for natural vitamin D synthesis, while practicing sun safety.
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International brand names for this medicine. Click a brand to search for detailed information.