Cortinex
Generic Name
Hydrocortisone Sodium Succinate
Manufacturer
Generic Pharmaceutical Company
Country
Global
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
cortinex 100 mg injection | ৳ 50.00 | N/A |
Description
Overview of the medicine
Cortinex 100 mg Injection contains Hydrocortisone Sodium Succinate, a potent corticosteroid used to treat various inflammatory conditions, allergic reactions, and as a replacement therapy for adrenal insufficiency. It is administered parenterally for rapid action.
Uses & Indications
Dosage
Adults
Dosage varies widely based on condition and severity. Typical range for severe conditions: 100-500 mg IV/IM, repeated every 2-6 hours as necessary. For adrenal crisis: 100 mg IV, followed by infusion.
Elderly
No specific dose adjustments required, but caution is advised due to increased risk of side effects.
Renal_impairment
No specific dose adjustment typically needed, but monitor closely.
How to Take
Administer intravenously (IV) or intramuscularly (IM). For IV administration, it can be given as a slow injection over 1-10 minutes or as an infusion. Reconstitute the powder with the provided solvent.
Mechanism of Action
Hydrocortisone acts by binding to intracellular glucocorticoid receptors, modulating gene expression, and thus influencing numerous physiological processes. It exerts potent anti-inflammatory, immunosuppressive, and anti-allergic effects by inhibiting the release of inflammatory mediators, suppressing immune responses, and reducing capillary permeability.
Pharmacokinetics
Onset
Rapid (within minutes after IV administration)
Excretion
Excreted mainly by the kidneys as inactive metabolites and some unchanged drug.
Half life
Biological half-life 8-12 hours; plasma half-life approximately 1.5-2 hours.
Absorption
Rapidly and completely absorbed after intramuscular or intravenous administration.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Systemic fungal infections (unless anti-fungal treatment is concurrently administered)
- Known hypersensitivity to hydrocortisone or any component of the formulation
- Live or live-attenuated vaccines during high-dose corticosteroid therapy
Drug Interactions
Anticoagulants (e.g., Warfarin)
Concomitant use may alter anticoagulant effects; monitor INR.
CYP3A4 inducers (e.g., Rifampin, Phenytoin)
May decrease hydrocortisone levels, requiring increased hydrocortisone dosage.
Diuretics (e.g., Thiazides, Loop diuretics)
May enhance potassium depletion.
CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase hydrocortisone levels, potentially leading to increased side effects.
Storage
Store below 25°C, protect from light and moisture. Do not freeze. Reconstituted solution should be used immediately.
Overdose
Acute overdose is rare. Symptoms may include fluid retention, hypertension, hyperglycemia, and potassium loss. Treatment is supportive; gradual withdrawal is key for chronic overdose.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Corticosteroids are excreted in breast milk; caution advised. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored unopened, refer to packaging for exact date.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of hydrocortisone for its approved indications. Ongoing research explores new applications and formulations.
Lab Monitoring
- Blood glucose levels (especially in diabetics)
- Electrolyte levels (particularly potassium)
- Blood pressure
- Bone mineral density (for long-term use)
- Ophthalmic examinations (for long-term use)
Doctor Notes
- Monitor patient for signs of infection, fluid retention, and electrolyte imbalance.
- Gradual tapering is crucial for patients on long-term therapy to prevent adrenal crisis.
- Advise patients on diet modifications (low sodium, high calcium/potassium) and blood glucose monitoring.
Patient Guidelines
- Do not stop treatment abruptly without consulting a doctor, especially after prolonged use.
- Report any signs of infection (fever, sore throat) immediately.
- Avoid close contact with people who have measles or chickenpox if you haven't had them.
- Carry an identification card stating that you are on corticosteroid therapy.
Missed Dose Advice
Since this is an acute care injection, missed doses should be avoided. If a scheduled dose is missed, administer as soon as remembered if medically appropriate, or consult the healthcare provider.
Driving Precautions
Cortinex 100 mg Injection is unlikely to affect the ability to drive or operate machinery. However, if you experience dizziness, blurred vision, or confusion, avoid these activities.
Lifestyle Advice
- Maintain a diet rich in calcium and vitamin D to support bone health.
- Limit sodium intake to prevent fluid retention and manage blood pressure.
- Engage in regular, moderate exercise to help maintain muscle strength and bone density.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.