Hydrocortisone
Generic Name
Hydrocortisone 5 mg Oral Solution
Manufacturer
Various Generic Manufacturers
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cortisol 5 mg oral solution | ৳ 65.00 | N/A |
Description
Overview of the medicine
Hydrocortisone is a corticosteroid hormone used to treat a variety of inflammatory and autoimmune conditions, as well as adrenal insufficiency. The 5 mg oral solution is often used in pediatric populations or for precise dosing.
Uses & Indications
Dosage
Adults
Dosage varies widely based on indication and severity. For adrenal insufficiency, typical maintenance is 20-30 mg/day, often divided. For inflammatory conditions, higher doses may be used short-term, e.g., 20-240 mg/day.
Elderly
Lower initial doses may be considered due to potential for increased sensitivity to side effects. Close monitoring is recommended.
Renal_impairment
No specific dose adjustment is generally required, but caution is advised in severe renal disease due to potential fluid retention.
How to Take
Take orally, usually with food or milk to minimize gastrointestinal irritation. Measure dose accurately using the provided dosing syringe or spoon. Take exactly as prescribed by your doctor.
Mechanism of Action
Hydrocortisone binds to glucocorticoid receptors, modifying gene expression, reducing inflammation, suppressing immune response, and affecting carbohydrate, protein, and fat metabolism.
Pharmacokinetics
Onset
Rapid, typically within an hour for biological effects.
Excretion
Excreted renally as inactive metabolites and some unchanged drug.
Half life
Plasma half-life is approximately 1.5 to 2 hours. Biological half-life is 8 to 12 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract following oral administration. Peak plasma levels usually occur within 1 to 2 hours.
Metabolism
Primarily metabolized in the liver (CYP3A4 pathway) and also to a lesser extent in the kidneys.
Side Effects
Contraindications
- •Systemic fungal infections (unless treated)
- •Hypersensitivity to hydrocortisone or any component of the formulation
Drug Interactions
Diuretics (e.g., thiazides, loop diuretics)
May enhance potassium depletion.
Non-steroidal anti-inflammatory drugs (NSAIDs)
Increased risk of gastrointestinal bleeding and ulceration.
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May significantly increase hydrocortisone plasma concentrations and effects.
CYP3A4 inducers (e.g., rifampin, phenytoin, barbiturates)
May decrease hydrocortisone plasma concentrations and reduce its effectiveness.
Storage
Store at room temperature (15-30°C), protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is rare. Chronic overdose can lead to signs and symptoms of Cushing's syndrome (e.g., moon face, central obesity, striae). Management involves symptomatic and supportive treatment, gradual reduction of the dose.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Hydrocortisone is excreted in breast milk; monitor infants for signs of adrenal suppression or other adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years for unopened bottles. Specific shelf-life after opening may vary by manufacturer, often 28 days.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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