Adults

For common intestinal worms (Ascariasis, Hookworm, Pinworm, Whipworm): 400 mg as a single dose. For Strongyloidiasis/Taeniasis: 400 mg once daily for 3 days. For Hydatid disease/Neurocysticercosis: 400 mg twice daily for specific durations as per physician's advice.

Elderly

No specific dose adjustment is generally required, but caution is advised in those with pre-existing hepatic or renal impairment.

Renal_impairment

No dosage adjustment is required for mild to moderate renal impairment. Use with caution in severe renal impairment as the active metabolite is primarily excreted via bile.

Onset

Onset of action varies depending on the indication and parasite type, typically requiring several days of treatment for some systemic infections.

Excretion

Primarily excreted via bile as the sulfoxide metabolite. A small amount is excreted renally.

Half life

Albendazole itself has a short half-life. Its active metabolite, albendazole sulfoxide, has a plasma half-life of approximately 8-12 hours.

Absorption

Albendazole is poorly absorbed from the gastrointestinal tract. Absorption is significantly increased when taken with a fatty meal.

Metabolism

Extensively metabolized in the liver to its primary active metabolite, albendazole sulfoxide, and then to albendazole sulfone and other inactive metabolites.

Theophylline

Albendazole may increase theophylline levels; monitoring of serum theophylline levels is recommended.

Cimetidine, Dexamethasone, Praziquantel

These drugs may increase plasma concentrations of albendazole sulfoxide, potentially leading to increased side effects.