Cospra
Generic Name
Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cospra 20 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Cospra 20 mg Tablet is a proton pump inhibitor (PPI) used to treat conditions caused by excess stomach acid, such as gastroesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome. It works by reducing the amount of acid produced in the stomach.
Uses & Indications
Dosage
Adults
For erosive esophagitis: 20 mg or 40 mg once daily for 4-8 weeks. For symptomatic GERD: 20 mg once daily for 4 weeks. For H. pylori eradication: 20 mg twice daily for 10 days (in combination with antibiotics).
Elderly
No dosage adjustment usually required, but monitor for adverse effects.
Renal_impairment
No dosage adjustment usually required.
How to Take
Swallow the tablet whole, do not crush or chew. Take at least one hour before a meal, preferably in the morning.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that works by irreversibly binding to the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells, thereby inhibiting the final step in gastric acid secretion.
Pharmacokinetics
Onset
Onset of acid suppression within 1 hour; full effect within 3-4 days.
Excretion
Primarily via urine (80%) and feces (20%).
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration, bioavailability is about 50-68%.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
May increase digoxin levels.
Warfarin
Increased INR and prothrombin time, requiring monitoring.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel.
Methotrexate
Increased methotrexate levels, especially with high doses.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, treatment should be symptomatic and supportive. Esomeprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and the potential benefits outweigh the potential risks. Caution is advised when administered to a nursing mother as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Generics available, original patent expired
WHO Essential Medicine
YesClinical Trials
Esomeprazole has been extensively studied in numerous clinical trials demonstrating efficacy and safety for acid-related disorders, including GERD, erosive esophagitis, and H. pylori eradication.
Lab Monitoring
- For long-term use (typically >3 months), monitor magnesium levels periodically.
- Monitor Vitamin B12 levels for prolonged therapy (>3 years).
Doctor Notes
- Advise patients on lifestyle modifications to complement PPI therapy.
- Counsel about potential risks with long-term use (e.g., C. difficile, fractures, hypomagnesemia, B12 deficiency).
- Re-evaluate the need for continued PPI therapy periodically, considering the lowest effective dose for the shortest duration necessary.
- Consider drug interactions with clopidogrel and warfarin.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking it without consulting your doctor, even if you feel better.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Seek medical attention if severe or persistent side effects occur.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods (e.g., spicy, fatty foods, caffeine, alcohol).
- Avoid lying down immediately after meals.
- Elevate the head of your bed while sleeping.
- Manage weight if overweight or obese.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.