Costin
Generic Name
Colistin Sulfate
Manufacturer
Drug Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| costin 500 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Costin 500 mg Tablet contains Colistin Sulfate, an antibiotic primarily used to treat certain bacterial infections in the gastrointestinal tract due to its poor systemic absorption.
Uses & Indications
Dosage
Adults
For gastrointestinal infections: 1.5-3 million international units (IU) per day, divided into 2-3 doses. Each 500 mg tablet typically corresponds to 1.5 million IU. Dosage must be determined by a physician.
Elderly
No specific dose adjustment for elderly patients based on age alone, but renal function should be monitored.
Renal_impairment
Since systemic absorption is minimal with oral Colistin Sulfate, severe renal impairment does not typically require dosage adjustment for GI tract indications. However, caution is advised and physician consultation is necessary.
How to Take
Take the tablet orally with water, as directed by your physician. It can be taken with or without food.
Mechanism of Action
Colistin is a polymyxin antibiotic that acts by disrupting the bacterial cell membrane, leading to increased permeability and leakage of intracellular contents, ultimately causing bacterial cell death.
Pharmacokinetics
Onset
Varies by indication, local effect in GI tract within hours.
Excretion
Primarily excreted unchanged in feces after oral administration due to poor absorption. Any systemically absorbed drug is excreted via the kidneys.
Half life
Systemic half-life is approximately 2-3 hours (for absorbed portion). For oral use, not clinically significant due to minimal absorption.
Absorption
Poorly absorbed from the gastrointestinal tract, making it suitable for local action within the gut. Systemic absorption is minimal.
Metabolism
Minimal hepatic metabolism.
Side Effects
Contraindications
- Known hypersensitivity to Colistin or any polymyxin antibiotics
- Patients with myasthenia gravis (relative contraindication due to potential neuromuscular blockade if significant systemic absorption occurs)
Drug Interactions
Nephrotoxic drugs
Concomitant use with other nephrotoxic drugs (e.g., aminoglycosides, amphotericin B, ciclosporin) may increase the risk of kidney damage if systemic absorption occurs.
Neuromuscular blocking agents
May potentiate the effect of neuromuscular blocking agents if systemic absorption occurs, leading to prolonged respiratory depression.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Due to poor systemic absorption, oral overdose is unlikely to cause systemic toxicity unless there is significant disruption of the GI mucosal barrier. Symptoms would primarily be gastrointestinal. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown if colistin is excreted in human milk; use with caution during lactation and weigh benefits against risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by health authorities
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Colistin's efficacy for certain infections is well-established, though new trials continue to explore its role in multidrug-resistant infections, including oral formulations for specific GI indications.
Lab Monitoring
- Renal function tests (for prolonged use or systemic absorption concern)
- Electrolyte levels (if diarrhea is severe)
Doctor Notes
- Emphasize the importance of completing the full course.
- Advise patients on potential GI side effects.
- Counsel patients on minimal systemic absorption and primary use for GI conditions.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Do not share this medicine with others.
- Store in a cool, dry place away from direct sunlight.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain good hydration, especially if experiencing diarrhea.
- Follow a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.