Coxetori
Generic Name
Etoricoxib
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| coxetori 120 mg tablet | ৳ 12.00 | N/A |
Description
Overview of the medicine
Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2). It is used to relieve pain and inflammation in various conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gouty arthritis.
Uses & Indications
Dosage
Adults
For acute pain conditions (e.g., acute gouty arthritis, post-operative dental pain, primary dysmenorrhea): 120 mg once daily for a maximum of 8 days.
Elderly
No dosage adjustment is generally required, but caution is advised due to increased risk of side effects.
Renal_impairment
Not recommended for patients with severe renal impairment (creatinine clearance <30 mL/min). Caution in moderate renal impairment.
How to Take
Take orally, with or without food. Swallowing the tablet whole with a glass of water is recommended.
Mechanism of Action
Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2), which is responsible for the synthesis of prostaglandins involved in inflammation, pain, and fever. By inhibiting COX-2, etoricoxib reduces the production of these inflammatory mediators.
Pharmacokinetics
Onset
Onset of analgesic action typically occurs within 24 minutes for acute pain conditions.
Excretion
Excreted predominantly via urine (approximately 70%) and feces (approximately 20%) as inactive metabolites.
Half life
The elimination half-life is approximately 22 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 1 hour (Tmax). Absolute bioavailability is approximately 100%.
Metabolism
Extensively metabolized in the liver, primarily via cytochrome P450 (CYP) enzymes, mainly CYP3A4, to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to etoricoxib or any other NSAID
- •Active peptic ulceration or gastrointestinal bleeding
- •Severe hepatic dysfunction
- •Severe renal impairment (CrCl <30 mL/min)
- •Congestive heart failure (NYHA Class II-IV)
- •Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
- •Uncontrolled hypertension
- •Pregnancy and lactation
Drug Interactions
Lithium
May increase plasma lithium levels, leading to lithium toxicity.
Warfarin
May increase the anticoagulant effect of warfarin, increasing bleeding risk.
Methotrexate
May increase plasma concentrations of methotrexate, enhancing its toxicity.
Oral Contraceptives
May increase plasma concentrations of ethinyl estradiol, potentially increasing adverse effects of oral contraceptives.
Ciclosporin, Tacrolimus
May increase the nephrotoxic effects of ciclosporin or tacrolimus.
Diuretics, ACE inhibitors, Angiotensin Receptor Blockers (ARBs)
May reduce the antihypertensive effect of these drugs and increase the risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, adverse events may include gastrointestinal disturbances, renal toxicity, and cardiovascular effects. Treatment is symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Etoricoxib is contraindicated during pregnancy and lactation. NSAIDs used in the third trimester of pregnancy can cause premature closure of the fetal ductus arteriosus and fetal renal dysfunction. It is unknown whether etoricoxib is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on storage conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent, generic available
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Global Brand Names
International brand names for this medicine
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