Coxia
Generic Name
Etoricoxib
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| coxia 90 mg tablet | ৳ 12.09 | ৳ 120.90 |
Description
Overview of the medicine
Coxia 90 mg Tablet contains Etoricoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, used for relieving pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and acute gouty arthritis.
Uses & Indications
Dosage
Adults
Osteoarthritis: 30 mg or 60 mg once daily. Rheumatoid Arthritis/Ankylosing Spondylitis: 60 mg or 90 mg once daily. Acute Gouty Arthritis: 120 mg once daily for a maximum of 8 days. Acute Pain/Primary Dysmenorrhea: 90 mg or 120 mg once daily for acute conditions, for shortest duration.
Elderly
No dose adjustment is generally necessary, but caution is advised due to potential age-related decrease in renal and hepatic function.
Renal_impairment
For mild renal impairment, no dose adjustment. For moderate renal impairment, a maximum of 60 mg once daily is recommended. Not recommended for severe renal impairment.
How to Take
Take orally, with or without food. It can be taken once daily. Swallow the tablet whole with water.
Mechanism of Action
Etoricoxib selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins involved in pain, inflammation, and fever. By inhibiting COX-2, it reduces the production of these inflammatory mediators.
Pharmacokinetics
Onset
Within 1 hour for analgesic effect.
Excretion
Primarily excreted via the urine (approximately 70%) and feces (approximately 20%) as metabolites.
Half life
Approximately 22 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached in approximately 1 hour.
Metabolism
Extensively metabolized, primarily via cytochrome P450 (CYP) enzymes, particularly CYP3A4, to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Etoricoxib or any excipients
- Active peptic ulceration or gastrointestinal bleeding
- Severe hepatic dysfunction
- Severe renal impairment (CrCl <30 mL/min)
- Congestive heart failure (NYHA Class II-IV)
- Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
- Uncontrolled hypertension
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding, monitor INR.
Diuretics
Reduced diuretic and antihypertensive effects.
Methotrexate
Increased plasma methotrexate levels, potentially increasing toxicity.
Oral contraceptives
Increased plasma concentrations of ethinyl estradiol, potentially increasing side effects.
ACE inhibitors/Angiotensin II receptor antagonists
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive and symptomatic treatment should be initiated. There is no specific antidote.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the third trimester due to potential adverse effects on the fetus. Avoid during breastfeeding as Etoricoxib is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to Etoricoxib or any excipients
- Active peptic ulceration or gastrointestinal bleeding
- Severe hepatic dysfunction
- Severe renal impairment (CrCl <30 mL/min)
- Congestive heart failure (NYHA Class II-IV)
- Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
- Uncontrolled hypertension
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding, monitor INR.
Diuretics
Reduced diuretic and antihypertensive effects.
Methotrexate
Increased plasma methotrexate levels, potentially increasing toxicity.
Oral contraceptives
Increased plasma concentrations of ethinyl estradiol, potentially increasing side effects.
ACE inhibitors/Angiotensin II receptor antagonists
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive and symptomatic treatment should be initiated. There is no specific antidote.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the third trimester due to potential adverse effects on the fetus. Avoid during breastfeeding as Etoricoxib is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved (e.g., DGDA, EMA)
Patent Status
Patent expired, generics available
Clinical Trials
Etoricoxib has undergone extensive clinical trials demonstrating its efficacy and safety profile for various indications, comparing it with other NSAIDs and placebo.
Lab Monitoring
- Blood pressure monitoring (regularly)
- Liver function tests (periodically, especially with long-term use)
- Renal function tests (periodically, especially in patients with pre-existing impairment)
- Complete blood count (CBC) to monitor for GI bleeding
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Carefully assess cardiovascular and gastrointestinal risk factors before initiating and during treatment.
- Monitor blood pressure regularly, especially in hypertensive patients.
- Avoid in patients with significant cardiovascular disease or uncontrolled hypertension.
Patient Guidelines
- Take exactly as prescribed by your doctor. Do not exceed the recommended dose.
- Report any unusual symptoms, especially gastrointestinal bleeding or cardiovascular issues, to your doctor immediately.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Long-term use should be carefully monitored due to cardiovascular and gastrointestinal risks.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or blurred vision. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid smoking and excessive alcohol consumption, as these can increase the risk of gastrointestinal side effects.
- Maintain a healthy diet and engage in regular, moderate exercise (if your condition allows) to support overall joint health.
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