Coxsafe

Take orally with or without food. Taking with food may help reduce gastrointestinal upset. Swallow the capsule whole with water.

Celecoxib selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which is primarily responsible for the synthesis of prostaglandins involved in inflammation, pain, and fever. By inhibiting COX-2, celecoxib reduces the production of these inflammatory mediators, thereby exerting its analgesic, anti-inflammatory, and antipyretic effects, while preserving the COX-1 enzyme which is responsible for gastric protection and platelet function.

• Hypersensitivity to celecoxib, sulfonamides, or any component of the formulation.
• History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
• Active peptic ulceration or gastrointestinal bleeding.
• Severe heart failure (NYHA Class IV).
• Advanced renal disease.
• Severe hepatic impairment.
• Third trimester of pregnancy.
• Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms following acute NSAID overdoses are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression, and coma may occur rarely. Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs and may occur following an overdose. Treatment is symptomatic and supportive. There is no specific antidote. Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion are unlikely to be useful due to high protein binding.

Pregnancy Category C in first and second trimesters, D in third trimester. Avoid celecoxib in late pregnancy due to potential for premature closure of the fetal ductus arteriosus. Use with caution early in pregnancy only if potential benefits outweigh risks. It is excreted into breast milk; use with caution in nursing mothers or consider alternative treatment.

• Hypersensitivity to celecoxib, sulfonamides, or any component of the formulation.
• History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
• Active peptic ulceration or gastrointestinal bleeding.
• Severe heart failure (NYHA Class IV).
• Advanced renal disease.
• Severe hepatic impairment.
• Third trimester of pregnancy.
• Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms following acute NSAID overdoses are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression, and coma may occur rarely. Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs and may occur following an overdose. Treatment is symptomatic and supportive. There is no specific antidote. Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion are unlikely to be useful due to high protein binding.

Pregnancy Category C in first and second trimesters, D in third trimester. Avoid celecoxib in late pregnancy due to potential for premature closure of the fetal ductus arteriosus. Use with caution early in pregnancy only if potential benefits outweigh risks. It is excreted into breast milk; use with caution in nursing mothers or consider alternative treatment.