Coxtop

Coxtop tablets should be swallowed whole with water, with or without food. Taking with food may reduce gastrointestinal upset.

Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2), an enzyme responsible for the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. By inhibiting COX-2, it reduces the production of these inflammatory prostaglandins, thereby alleviating pain and inflammation, while theoretically preserving gastrointestinal protective COX-1 activity.

• Hypersensitivity to etoricoxib or any component of the formulation
• Active peptic ulceration or gastrointestinal bleeding
• Severe liver dysfunction
• Severe uncontrolled heart failure
• Ischaemic heart disease, peripheral arterial disease, cerebrovascular disease
• Previous history of bronchospasm, acute rhinitis, nasal polyps, angioneurotic edema, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms of overdose may include gastrointestinal disturbances, somnolence, and lethargy. Management is supportive; there is no specific antidote. Gastric decontamination (e.g., activated charcoal) may be considered if ingestion is recent.

Not recommended during pregnancy, especially in the third trimester, due to potential risks to the fetus (e.g., premature closure of the ductus arteriosus). Avoid during lactation as it may be excreted in breast milk.

• Hypersensitivity to etoricoxib or any component of the formulation
• Active peptic ulceration or gastrointestinal bleeding
• Severe liver dysfunction
• Severe uncontrolled heart failure
• Ischaemic heart disease, peripheral arterial disease, cerebrovascular disease
• Previous history of bronchospasm, acute rhinitis, nasal polyps, angioneurotic edema, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms of overdose may include gastrointestinal disturbances, somnolence, and lethargy. Management is supportive; there is no specific antidote. Gastric decontamination (e.g., activated charcoal) may be considered if ingestion is recent.

Not recommended during pregnancy, especially in the third trimester, due to potential risks to the fetus (e.g., premature closure of the ductus arteriosus). Avoid during lactation as it may be excreted in breast milk.