Cozaril
Generic Name
Losartan Potassium 50 mg Tablet
Manufacturer
Merck Sharp & Dohme (MSD)
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cozaril 50 mg tablet | ৳ 4.03 | N/A |
Description
Overview of the medicine
Losartan is used to treat high blood pressure, reduce the risk of stroke in patients with high blood pressure and an enlarged heart, and to treat kidney disease in patients with type 2 diabetes and high blood pressure.
Uses & Indications
Dosage
Adults
Initial dose 50 mg once daily, may be increased to 100 mg once daily or divided doses.
Elderly
No initial dosage adjustment generally needed, but monitor closely.
Renal_impairment
No initial dosage adjustment needed for mild to moderate impairment; consider lower starting dose for severe impairment or dialysis patients (25 mg once daily).
How to Take
Oral administration, with or without food.
Mechanism of Action
Blocks the binding of angiotensin II to the AT1 receptor, preventing vasoconstriction and aldosterone release.
Pharmacokinetics
Onset
6 hours for maximal effect.
Excretion
Excreted via urine (35%) and feces (60%) as unchanged drug and metabolites.
Half life
Losartan: 2 hours; active metabolite (E-3174): 6-9 hours.
Absorption
Well absorbed orally, undergoes extensive first-pass metabolism. Bioavailability is about 33%. Peak plasma concentrations within 1 hour for losartan, 3-4 hours for active metabolite.
Metabolism
Extensive hepatic metabolism (CYP2C9 and CYP3A4) to an active carboxylic acid metabolite (E-3174).
Side Effects
Contraindications
- Hypersensitivity to losartan or any component
- Pregnancy (second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment
Drug Interactions
NSAIDs
May attenuate antihypertensive effect, increased risk of renal impairment.
Lithium
Increased serum lithium concentrations and toxicity.
Diuretics/other antihypertensives
Increased hypotensive effect.
Potassium-sparing diuretics/potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypotension and tachycardia; bradycardia may occur. Treatment is symptomatic and supportive. Hemodialysis is not effective.
Pregnancy & Lactation
Category D in 2nd and 3rd trimesters. Not recommended during breastfeeding due to potential harm to infant.
Side Effects
Contraindications
- Hypersensitivity to losartan or any component
- Pregnancy (second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment
Drug Interactions
NSAIDs
May attenuate antihypertensive effect, increased risk of renal impairment.
Lithium
Increased serum lithium concentrations and toxicity.
Diuretics/other antihypertensives
Increased hypotensive effect.
Potassium-sparing diuretics/potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypotension and tachycardia; bradycardia may occur. Treatment is symptomatic and supportive. Hemodialysis is not effective.
Pregnancy & Lactation
Category D in 2nd and 3rd trimesters. Not recommended during breastfeeding due to potential harm to infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (check specific packaging)
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA (USA), DGDA (Bangladesh)
Patent Status
Patent expired (generic versions available)
WHO Essential Medicine
YesClinical Trials
Key trials include the LIFE (Losartan Intervention For Endpoint reduction in hypertension) study and RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) study, demonstrating benefits in hypertension, stroke risk reduction, and diabetic nephropathy.
Lab Monitoring
- Serum potassium levels
- Renal function (BUN, creatinine)
- Blood pressure
Doctor Notes
- Monitor renal function and serum potassium periodically, especially in patients with pre-existing renal impairment or those on potassium-sparing diuretics.
- Advise patients on lifestyle modifications to enhance blood pressure control.
- Educate female patients about the risks of pregnancy during therapy.
Patient Guidelines
- Take medicine regularly at the same time each day.
- Do not stop taking the medicine without consulting your doctor.
- Monitor your blood pressure as advised by your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose.
Driving Precautions
May cause dizziness or fatigue, use caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a low-sodium diet.
- Engage in regular physical activity.
- Avoid excessive alcohol consumption and smoking.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.