Cozid
Generic Name
Azithromycin
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cozid 250 mg injection | ৳ 85.00 | N/A |
Description
Overview of the medicine
Cozid 250 mg Injection contains Azithromycin, a macrolide antibiotic used to treat various bacterial infections. It works by inhibiting bacterial protein synthesis.
Uses & Indications
Dosage
Adults
For Cozid 250 mg Injection, typically 250 mg once daily for 2-5 days depending on the type and severity of infection. For CAP and PID, higher initial doses of 500 mg IV as a single daily dose for 1-2 days may be followed by oral therapy or continued IV.
Elderly
No specific dose adjustment needed unless severe renal or hepatic impairment is present.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Caution with severe impairment.
How to Take
For intravenous infusion only. Administer slowly over 60 minutes. Do not administer as a bolus.
Mechanism of Action
Azithromycin binds to the 50S ribosomal subunit of susceptible microorganisms, thereby inhibiting protein synthesis and interfering with nucleic acid synthesis.
Pharmacokinetics
Onset
Rapid, typically within hours for IV administration.
Excretion
Primarily excreted unchanged in bile; a small percentage is excreted renally.
Half life
Prolonged, ranging from 2 to 4 days due to extensive tissue uptake and slow release.
Absorption
Rapidly absorbed after intravenous administration, leading to high tissue concentrations.
Metabolism
Minor hepatic metabolism; primarily demethylation.
Side Effects
Contraindications
- Hypersensitivity to Azithromycin, Erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior Azithromycin use.
Drug Interactions
Antacids
May decrease peak serum levels. Administer Azithromycin at least 1 hour before or 2 hours after antacids.
Warfarin
Potentiates the anticoagulant effect, requiring close monitoring of INR.
Nelfinavir
May increase Azithromycin serum concentrations.
QT-prolonging drugs
Increased risk of cardiac arrhythmias. Avoid co-administration with other drugs known to prolong the QT interval.
Storage
Store below 30°C in a dry place, protected from light. Do not freeze. Reconstituted solution should be used immediately.
Overdose
Symptoms may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored as recommended.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Azithromycin's efficacy and safety for indicated bacterial infections. Specific trials for Cozid brand confirm bioequivalence.
Lab Monitoring
- Liver function tests (LFTs) especially in patients with pre-existing hepatic impairment.
- Renal function tests for prolonged therapy.
- Complete blood count (CBC).
- ECG monitoring in patients at risk for QT prolongation.
Doctor Notes
- Ensure patient is not hypersensitive to macrolides before administration.
- Monitor for signs of C. difficile infection, especially with persistent diarrhea.
- Caution in patients with prolonged QT interval, hypokalemia, or hypomagnesemia.
- Assess hepatic and renal function in patients with pre-existing conditions.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Report any severe or persistent side effects to your doctor immediately.
- Do not share this medication with others.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cozid is generally not expected to impair the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid driving.
Lifestyle Advice
- Maintain good hydration during treatment.
- Get adequate rest to support recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.