Creston 20 mg tablet can be taken at any time of day, with or without food. It is recommended to take it at the same time each day to maintain consistent blood levels.

Rosuvastatin selectively and competitively inhibits HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor to cholesterol. This inhibition reduces cholesterol synthesis in the liver and increases the number of LDL receptors on the hepatocyte surface, enhancing uptake and catabolism of LDL.

• •Hypersensitivity to rosuvastatin or any component of the product
• •Active liver disease, including unexplained persistent elevations of serum transaminases
• •Severe renal impairment (CrCl <30 mL/min)
• •Myopathy
• •Concomitant cyclosporine use
• •Pregnancy and lactation

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

No specific antidote. Management involves symptomatic treatment and supportive measures. Monitor liver function and CK levels. Hemodialysis is unlikely to be of benefit.

Contraindicated during pregnancy and lactation. Statins can cause fetal harm. Women of childbearing potential should use effective contraception.