Crotam-Plus
Generic Name
Crotamiton + Sulfur
Manufacturer
Reputable Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| crotam plus 5 10 lotion | ৳ 140.00 | N/A |
Description
Overview of the medicine
Crotam-Plus 5-10 Lotion is a topical medication containing Crotamiton 10% w/v and Sulfur 5% w/v. It is primarily used for the treatment of scabies and relief of pruritus (itching) associated with various dermatological conditions.
Uses & Indications
Dosage
Adults
For scabies: Apply a thin layer to the entire body surface from the neck down, once daily for 3-5 days. Reapply after bathing. For pruritus: Apply to affected areas 2-3 times daily until itching subsides.
Elderly
No specific dosage adjustment required; use as per adult dosage.
Renal_impairment
No specific dosage adjustment required for topical use as systemic absorption is minimal.
How to Take
Wash and dry the skin thoroughly before application. For scabies, apply to the entire body from the neck down, paying attention to skin folds, between fingers and toes, and under nails. Avoid contact with eyes, mouth, and other mucous membranes. Repeat application as directed. For pruritus, apply to the affected area and rub in gently.
Mechanism of Action
Crotamiton acts as a scabicide and antipruritic. Its exact mechanism as a scabicide is unknown but thought to involve neurotoxic effects on the mites. As an antipruritic, it may exert a local anesthetic effect. Sulfur acts as a keratolytic, mild antiseptic, and weak antiparasitic agent. It is thought to exert its effect through conversion to hydrogen sulfide by epidermal cells, which is toxic to mites.
Pharmacokinetics
Onset
Antipruritic effect of Crotamiton may be observed within 30 minutes to an hour. Scabicidal action requires several days of application.
Excretion
Metabolites of Crotamiton are excreted via the kidneys. Sulfur is largely excreted via the skin and feces.
Half life
Not well established for topical Crotamiton or Sulfur due to limited systemic absorption.
Absorption
Crotamiton is absorbed percutaneously to a small extent (less than 10%) after topical application. Sulfur has minimal systemic absorption when applied topically.
Metabolism
Absorbed Crotamiton is metabolized in the liver. Sulfur metabolism involves conversion to sulfides in the skin.
Side Effects
Contraindications
- •Hypersensitivity to Crotamiton, Sulfur, or any component of the formulation
- •Acute exudative dermatoses
- •Do not apply to acutely inflamed, broken, or weeping skin
- •Infants and young children without medical advice
Drug Interactions
Other topical preparations
Avoid concurrent use of other irritating topical preparations, especially those containing exfoliating agents, as this may increase skin irritation or absorption.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze.
Overdose
Topical overdose is unlikely to cause systemic toxicity due to minimal absorption. Excessive application may lead to increased local skin irritation. In case of accidental ingestion, seek immediate medical attention.
Pregnancy & Lactation
Consult a doctor before use during pregnancy or lactation. While systemic absorption is minimal, caution should be exercised. Do not apply to breasts if breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date (check product label)
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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