Cyclotox
Generic Name
Cyclotox 200 mg Injection
Manufacturer
OncoLife Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
cyclotox 200 mg injection | ৳ 180.00 | N/A |
Description
Overview of the medicine
Cyclotox 200 mg Injection is an antineoplastic agent used in the treatment of various types of cancer. It works by interfering with the growth of cancer cells, which are eventually destroyed. It is often used in combination with other chemotherapy drugs or radiation therapy.
Uses & Indications
Dosage
Adults
Dosage varies greatly based on the specific cancer, patient's condition, and combination therapy. Typical dose ranges from 500 mg/m² to 1200 mg/m² intravenously, administered every 3-4 weeks. Consult oncology protocol.
Elderly
Dosage may need to be adjusted based on renal and hepatic function, and overall health status. Close monitoring is recommended.
Renal_impairment
Dose reduction is necessary in patients with severe renal impairment (e.g., creatinine clearance < 10 mL/min). Consult specific guidelines.
How to Take
Cyclotox 200 mg Injection should be administered intravenously by a healthcare professional, usually as a slow infusion over 30-60 minutes, after proper dilution. Ensure adequate hydration.
Mechanism of Action
Cyclotox acts as an alkylating agent. It forms cross-links within DNA strands, preventing cell division and leading to apoptosis of rapidly dividing cells, particularly cancer cells. It is cell cycle non-specific.
Pharmacokinetics
Onset
Rapid, typically within minutes of administration.
Excretion
Mainly excreted by the kidneys (approximately 50-70% as metabolites and unchanged drug).
Half life
Approximately 4-8 hours for the active metabolites.
Absorption
Rapidly and completely absorbed after intravenous administration, 100% bioavailability.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes to active alkylating metabolites.
Side Effects
Contraindications
- Hypersensitivity to the active substance or any excipients
- Severe bone marrow depression (myelosuppression)
- Acute infections
- Severe cardiac insufficiency
- Pregnancy and lactation
Drug Interactions
Warfarin
May alter anticoagulant effect (increased or decreased).
Allopurinol
May increase bone marrow depression.
Vaccines (live)
Avoid due to immunosuppression; risk of severe infection.
Other myelosuppressive agents
Increased risk of severe myelosuppression.
Storage
Store below 25°C, protected from light. Do not freeze. Reconstituted solution stable for 24 hours at room temperature or 6 days refrigerated.
Overdose
Overdose symptoms include severe myelosuppression, nausea, vomiting, and diarrhea. Management is primarily supportive, including transfusions, antiemetics, and infection control. There is no specific antidote.
Pregnancy & Lactation
Cyclotox is contraindicated during pregnancy due to its teratogenic and embryotoxic potential. It is also contraindicated during lactation as it is excreted in breast milk and can harm the infant. Effective contraception should be used by both male and female patients during and after treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 years from manufacturing date
Availability
Available in hospitals and specialized oncology pharmacies
Approval Status
Approved for various malignancies
Patent Status
Patent expired, generic versions available
WHO Essential Medicine
YesClinical Trials
Ongoing phase IV studies are evaluating long-term safety and efficacy in various cancer types and in combination regimens. Phase III trials confirmed efficacy in lymphoma and breast cancer.
Lab Monitoring
- Complete Blood Count (CBC) with differential, frequently (before each dose and weekly)
- Renal function tests (Creatinine, BUN)
- Liver function tests (ALT, AST, Bilirubin)
- Urine analysis (for hematuria, to monitor for hemorrhagic cystitis)
- Electrolytes
Doctor Notes
- Strict monitoring of hematological parameters is crucial.
- Prophylaxis for hemorrhagic cystitis (e.g., Mesna) should be considered, especially with high doses.
- Assess cardiac and pulmonary function before and during treatment.
- Counsel patients on fertility preservation options.
Patient Guidelines
- Report any fever, chills, sore throat, or unusual bleeding/bruising immediately.
- Maintain good oral hygiene to prevent mucositis.
- Stay well-hydrated by drinking plenty of fluids.
- Avoid contact with people who are sick or have infections.
Missed Dose Advice
If a dose is missed, contact your oncologist or healthcare provider immediately. Do not double the dose.
Driving Precautions
Cyclotox can cause fatigue, dizziness, or visual disturbances. Patients should avoid driving or operating machinery if they experience these side effects.
Lifestyle Advice
- Get adequate rest and manage fatigue.
- Eat a nutritious diet, consult a dietitian if needed.
- Avoid raw or undercooked foods to reduce infection risk.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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