Cynta
Generic Name
Tapentadol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cynta 100 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Cynta 100 mg Tablet contains Tapentadol, an opioid analgesic used to manage moderate to severe acute pain and chronic pain when around-the-clock opioid analgesia is required for an extended period.
Uses & Indications
Dosage
Adults
Acute Pain: 50 mg to 100 mg every 4 to 6 hours as needed. Chronic Pain: Initial dose 50 mg twice daily, titrate up to 250 mg twice daily based on patient response.
Elderly
Caution advised; start with lower doses and titrate slowly due to potential for decreased clearance.
Renal_impairment
Severe renal impairment (CrCl <30 mL/min): Not recommended. Moderate impairment: Use with caution, extend dosing interval.
How to Take
Oral administration. Tablets should be swallowed whole with sufficient liquid, with or without food.
Mechanism of Action
Tapentadol has a dual mechanism of action: it is a mu-opioid receptor agonist and a norepinephrine reuptake inhibitor. These actions contribute to its analgesic effects.
Pharmacokinetics
Onset
Within 30-60 minutes
Excretion
Primarily excreted renally (99% as metabolites).
Half life
Approximately 4 hours
Absorption
Rapidly and extensively absorbed (bioavailability approximately 32% due to first-pass metabolism).
Metabolism
Extensively metabolized, primarily via glucuronidation; CYP450 system plays a minor role.
Side Effects
Contraindications
- Significant respiratory depression
- Acute or severe bronchial asthma or hypercapnia in an unmonitored setting or in the absence of resuscitative equipment
- Known or suspected paralytic ileus
- Concomitant use of monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOIs
- Hypersensitivity to Tapentadol or any excipients
Drug Interactions
MAOIs
Concurrent use contraindicated; risk of serotonin syndrome or opioid toxicity.
Serotonergic Drugs (e.g., SSRIs, SNRIs, TCAs)
Increased risk of serotonin syndrome.
CNS Depressants (e.g., Benzodiazepines, alcohol, other opioids)
Increased risk of respiratory depression, profound sedation, coma, and death.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include respiratory depression, somnolence, pinpoint pupils, skeletal muscle flaccidity, cold and clammy skin, and in severe cases, circulatory collapse, coma, and death. Naloxone is the primary antidote for opioid overdose.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy, particularly near term, due to risk of neonatal opioid withdrawal syndrome. Excreted in breast milk; advise against breastfeeding.
Side Effects
Contraindications
- Significant respiratory depression
- Acute or severe bronchial asthma or hypercapnia in an unmonitored setting or in the absence of resuscitative equipment
- Known or suspected paralytic ileus
- Concomitant use of monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOIs
- Hypersensitivity to Tapentadol or any excipients
Drug Interactions
MAOIs
Concurrent use contraindicated; risk of serotonin syndrome or opioid toxicity.
Serotonergic Drugs (e.g., SSRIs, SNRIs, TCAs)
Increased risk of serotonin syndrome.
CNS Depressants (e.g., Benzodiazepines, alcohol, other opioids)
Increased risk of respiratory depression, profound sedation, coma, and death.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include respiratory depression, somnolence, pinpoint pupils, skeletal muscle flaccidity, cold and clammy skin, and in severe cases, circulatory collapse, coma, and death. Naloxone is the primary antidote for opioid overdose.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy, particularly near term, due to risk of neonatal opioid withdrawal syndrome. Excreted in breast milk; advise against breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have demonstrated efficacy in acute and chronic pain conditions, including osteoarthritis pain, low back pain, and neuropathic pain.
Lab Monitoring
- No specific routine lab monitoring required for healthy individuals. Monitor renal and hepatic function in impaired patients.
- Monitor for signs of respiratory depression and CNS depression.
Doctor Notes
- Assess patient's risk for opioid abuse before prescribing.
- Monitor for respiratory depression, especially during initiation or dose escalation.
- Educate patients about safe storage and disposal to prevent accidental ingestion or diversion.
Patient Guidelines
- Take exactly as prescribed.
- Do not crush, chew, or break the tablet.
- Avoid alcohol and other CNS depressants.
- Report any difficulty breathing or unusual drowsiness immediately.
- Do not stop taking the medicine suddenly without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness, somnolence, and impaired cognitive function. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain regular physical activity to help manage chronic pain.
- Stay hydrated and eat a balanced diet to manage constipation.
- Avoid activities requiring mental alertness until you know how the medicine affects you.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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