CZM
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| czm tablet | ৳ 4.00 | N/A |
Description
Overview of the medicine
Cefixime is an oral third-generation cephalosporin antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
200-400 mg once daily or 200 mg every 12 hours for 7-14 days depending on infection.
Elderly
No specific dose adjustment needed unless severe renal impairment.
Renal_impairment
Adjust dose for CrCl < 60 mL/min (e.g., 200 mg daily for CrCl 21-60 mL/min, 100 mg daily for CrCl < 20 mL/min).
How to Take
Can be taken with or without food. For best absorption, consistently take with or without food.
Mechanism of Action
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
Pharmacokinetics
Onset
Peak plasma concentrations reached in 2-6 hours.
Excretion
Primarily via kidney (renal excretion) with some biliary excretion.
Half life
Approximately 3-4 hours.
Absorption
Approximately 40-50% orally absorbed, food may slightly delay but not significantly alter absorption.
Metabolism
Limited metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of anaphylaxis to penicillin
Drug Interactions
Probenecid
Increases cefixime plasma levels and prolongs half-life.
Carbamazepine
Cefixime may increase carbamazepine levels; monitor for toxicity.
Anticoagulants (e.g., Warfarin)
May increase prothrombin time (INR); monitor closely.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include gastrointestinal upset (nausea, vomiting, diarrhea) and possibly neurological effects. Treatment is symptomatic and supportive; hemodialysis or peritoneal dialysis is not substantially beneficial.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk in small amounts; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of anaphylaxis to penicillin
Drug Interactions
Probenecid
Increases cefixime plasma levels and prolongs half-life.
Carbamazepine
Cefixime may increase carbamazepine levels; monitor for toxicity.
Anticoagulants (e.g., Warfarin)
May increase prothrombin time (INR); monitor closely.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include gastrointestinal upset (nausea, vomiting, diarrhea) and possibly neurological effects. Treatment is symptomatic and supportive; hemodialysis or peritoneal dialysis is not substantially beneficial.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk in small amounts; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generically available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety in various bacterial infections.
Lab Monitoring
- Renal function (especially in prolonged therapy or pre-existing renal impairment)
- INR if co-administered with anticoagulants
- Liver function tests (rarely)
Doctor Notes
- Counsel patients on importance of completing full course to prevent resistance.
- Be aware of potential for cross-reactivity in penicillin-allergic patients.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Do not share this medication with others.
- Inform your doctor about any allergies or other medications you are taking.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some individuals; exercise caution if driving or operating machinery.
Lifestyle Advice
- Stay hydrated.
- Avoid alcohol during treatment.
- Maintain good hygiene to prevent reinfection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.