D-Gain
Generic Name
Cholecalciferol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| d gain 20000 iu capsule | ৳ 20.00 | ৳ 160.00 |
Description
Overview of the medicine
D-Gain 20000 IU Capsule contains Cholecalciferol (Vitamin D3), which is essential for calcium and phosphate absorption and bone health. It is used to treat and prevent vitamin D deficiency and related conditions.
Uses & Indications
Dosage
Adults
For severe Vitamin D deficiency: 20,000 IU once weekly for 7 to 10 weeks, followed by a maintenance dose as determined by serum 25(OH)D levels. For maintenance, typically 800-2000 IU daily or equivalent weekly/monthly dose.
Elderly
Similar to adults. May require higher doses due to reduced skin synthesis and dietary intake. Individual assessment is crucial.
Renal_impairment
Use with caution. Monitor serum calcium, phosphate, and 25(OH)D levels regularly. Dosage adjustment may be necessary. Not recommended in severe renal impairment without specialized advice.
How to Take
Take the capsule orally, preferably with a meal (especially fatty foods) to enhance absorption. Swallow whole with water, do not chew or crush.
Mechanism of Action
Cholecalciferol (Vitamin D3) is biologically inactive but is hydroxylated in the liver to 25-hydroxyvitamin D (calcifediol) and then in the kidneys to 1,25-dihydroxyvitamin D (calcitriol), the active form. Calcitriol promotes intestinal absorption of calcium and phosphate, regulates bone mineralization, and maintains calcium homeostasis.
Pharmacokinetics
Onset
Therapeutic effects may take several days to weeks to manifest, as Cholecalciferol requires metabolic activation and accumulation.
Excretion
Mainly excreted via the bile into the feces. A small amount is excreted renally.
Half life
The half-life of 25-hydroxyvitamin D (calcifediol) is about 15-20 days, while the half-life of 1,25-dihydroxyvitamin D (calcitriol) is 4-6 hours. Stored vitamin D in adipose tissue can be released over several weeks.
Absorption
Cholecalciferol is readily absorbed from the small intestine, primarily in the presence of bile salts and dietary fat.
Metabolism
Initially hydroxylated in the liver by cytochrome P450 enzymes (e.g., CYP2R1, CYP27A1) to 25-hydroxyvitamin D (calcifediol), then further hydroxylated in the kidneys by 1-alpha-hydroxylase (CYP27B1) to 1,25-dihydroxyvitamin D (calcitriol).
Side Effects
Contraindications
- •Hypersensitivity to Cholecalciferol or any component of the formulation
- •Hypercalcemia (high levels of calcium in the blood)
- •Hypervitaminosis D (excessive levels of Vitamin D)
- •Severe renal osteodystrophy with hyperphosphatemia
Drug Interactions
Corticosteroids
May reduce the effect of Vitamin D.
Thiazide diuretics
May increase the risk of hypercalcemia.
Phenytoin, barbiturates
May accelerate the metabolism of Vitamin D, reducing its efficacy.
Cardiac glycosides (e.g., Digoxin)
Increased risk of toxicity due to potential hypercalcemia.
Orlistat, Cholestyramine, mineral oil
May impair absorption of Vitamin D.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose primarily relate to hypercalcemia and include nausea, vomiting, constipation, polyuria, polydipsia, weakness, headache, and confusion. Severe cases can lead to kidney damage, arrhythmias, and coma. Management involves discontinuation of Cholecalciferol, hydration, and medical supervision.
Pregnancy & Lactation
Pregnancy Category C. Adequate Vitamin D intake is crucial during pregnancy and lactation. However, high doses should be avoided. Consult your doctor to determine the appropriate dosage.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, drugstores
Approval Status
Approved
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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