Daclaxen
Generic Name
Daclaxen-60-mg-tablet
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| daclaxen 60 mg tablet | ৳ 395.00 | N/A |
Description
Overview of the medicine
Daclaxen 60 mg tablet is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
Oral: 60 mg once or twice daily, or as directed by physician. Max 120 mg/day.
Elderly
Lower doses may be required; caution advised due to increased risk of side effects. Consult physician.
Renal_impairment
Use with caution in mild to moderate impairment; contraindicated in severe renal impairment. Dose adjustment may be necessary under medical supervision.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Daclaxen works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Within 30 minutes for pain relief.
Excretion
Excreted mainly through urine (60-70%) and feces (30-40%) as metabolites.
Half life
Approximately 2-4 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes (CYP2C9, CYP2C8) to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to daclaxen or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effect.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE inhibitors/Angiotensin II receptor blockers
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive treatment; there is no specific antidote.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm and interference with labor. Use in early pregnancy and lactation only if clearly needed and benefits outweigh risks, under strict medical supervision.
Side Effects
Contraindications
- Hypersensitivity to daclaxen or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effect.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE inhibitors/Angiotensin II receptor blockers
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive treatment; there is no specific antidote.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm and interference with labor. Use in early pregnancy and lactation only if clearly needed and benefits outweigh risks, under strict medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Daclaxen has undergone clinical trials demonstrating its efficacy and safety in the management of pain and inflammatory conditions. Key trials focused on its analgesic and anti-inflammatory effects in osteoarthritis and rheumatoid arthritis patients.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs) - especially for long-term use or in elderly patients.
- Blood pressure monitoring.
Doctor Notes
- Advise patients to take Daclaxen with food to minimize GI adverse effects.
- Monitor renal function, liver function, and blood pressure in patients on long-term therapy.
- Caution in patients with a history of cardiovascular disease, GI issues, or asthma.
- Prescribe the lowest effective dose for the shortest possible duration consistent with individual patient treatment goals.
Patient Guidelines
- Do not exceed the recommended dose.
- Take with food to minimize stomach upset.
- Inform your doctor about any history of stomach ulcers, heart disease, or kidney problems.
- Avoid alcohol while taking this medicine.
- Seek immediate medical attention if you experience severe abdominal pain, black tarry stools, or unusual bleeding.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Daclaxen may cause dizziness or drowsiness in some individuals. Patients should be cautioned about driving or operating machinery until they are reasonably certain that Daclaxen does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Maintain a healthy diet to support overall well-being.
- Engage in regular, moderate exercise if appropriate for your condition.
- Limit alcohol intake.
- Report any new or worsening symptoms to your healthcare provider.
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Global Brand Names
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