Daprotab
Generic Name
Dapagliflozin
Manufacturer
Drug International Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| daprotab 1 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Dapagliflozin is an oral antidiabetic drug used to improve glycemic control in adults with type 2 diabetes mellitus, and for the treatment of heart failure with reduced ejection fraction and chronic kidney disease.
Uses & Indications
Dosage
Adults
For Type 2 Diabetes Mellitus: Initial dose is typically 5 mg once daily, may be increased to 10 mg once daily. For Heart Failure or CKD: 10 mg once daily. The 1 mg tablet may be used for specific titration or in very sensitive patients, though 5 mg is the usual starting dose.
Elderly
No dosage adjustment needed based on age, but consider renal function and risk of volume depletion.
Renal_impairment
Dose adjustment required based on eGFR. Not recommended if eGFR is below 25 mL/min/1.73m² for glucose lowering. For Heart Failure/CKD, initiation is not recommended if eGFR <25 mL/min/1.73m².
How to Take
Take orally, once daily, with or without food.
Mechanism of Action
It inhibits Sodium-Glucose Co-transporter 2 (SGLT2) in the renal tubules, leading to reduced glucose reabsorption and increased urinary glucose excretion, thereby lowering blood glucose levels.
Pharmacokinetics
Onset
Glucose lowering effect observed within hours of administration.
Excretion
Approximately 75% renally excreted and 21% fecally excreted, primarily as metabolites.
Half life
Approximately 12.9 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1 hour. High oral bioavailability.
Metabolism
Primarily metabolized by UGT1A9 to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to dapagliflozin or any excipients.
- Patients with severe renal impairment, end-stage renal disease (ESRD), or on dialysis.
Drug Interactions
Lithium
Dapagliflozin may decrease lithium concentrations. Monitor lithium levels.
Diuretics
May increase the risk of dehydration and hypotension.
Insulin and Insulin Secretagogues (e.g., sulfonylureas)
May increase the risk of hypoglycemia. A lower dose of insulin or sulfonylurea may be required.
Storage
Store below 30°C in a dry place, protected from light and moisture.
Overdose
In the event of an overdose, contact a poison control center or emergency room immediately. Symptomatic and supportive treatment should be initiated.
Pregnancy & Lactation
Not recommended during the second and third trimesters of pregnancy due to potential for adverse renal development in the fetus. Not recommended during breastfeeding as it may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to dapagliflozin or any excipients.
- Patients with severe renal impairment, end-stage renal disease (ESRD), or on dialysis.
Drug Interactions
Lithium
Dapagliflozin may decrease lithium concentrations. Monitor lithium levels.
Diuretics
May increase the risk of dehydration and hypotension.
Insulin and Insulin Secretagogues (e.g., sulfonylureas)
May increase the risk of hypoglycemia. A lower dose of insulin or sulfonylurea may be required.
Storage
Store below 30°C in a dry place, protected from light and moisture.
Overdose
In the event of an overdose, contact a poison control center or emergency room immediately. Symptomatic and supportive treatment should be initiated.
Pregnancy & Lactation
Not recommended during the second and third trimesters of pregnancy due to potential for adverse renal development in the fetus. Not recommended during breastfeeding as it may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies, Hospitals
Approval Status
FDA/DGDA approved
Patent Status
Off-patent (for generic availability)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials (e.g., DECLARE-TIMI 58, DAPA-HF, DAPA-CKD) have demonstrated the efficacy and safety of dapagliflozin for its approved indications.
Lab Monitoring
- Renal function (eGFR) should be assessed prior to initiation and periodically thereafter.
- Blood glucose and HbA1c levels to monitor glycemic control.
- Electrolyte levels may be monitored, especially in patients at risk for volume depletion.
Doctor Notes
- Emphasize patient education on hydration, genital hygiene, and symptoms of ketoacidosis and UTIs.
- Monitor renal function (eGFR) at baseline and periodically, especially in elderly or patients with pre-existing renal impairment.
- Consider dose adjustments when co-administered with diuretics or insulin/sulfonylureas.
Patient Guidelines
- Monitor blood sugar levels regularly as advised by your doctor.
- Stay well-hydrated by drinking plenty of fluids to prevent dehydration.
- Maintain good personal hygiene to reduce the risk of genital and urinary tract infections.
- Report any symptoms of diabetic ketoacidosis (e.g., nausea, vomiting, abdominal pain, rapid breathing) or serious urinary tract infections immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a forgotten dose.
Driving Precautions
Caution is advised if you experience dizziness or symptoms of hypoglycemia, especially if taken with insulin or sulfonylureas. Avoid driving or operating heavy machinery if affected.
Lifestyle Advice
- Adopt a healthy, balanced diet recommended for diabetes management.
- Engage in regular physical activity as part of your diabetes care plan.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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