Darbagen
Generic Name
Darbepoetin Alfa
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| darbagen 100 mcg injection | ৳ 9,090.00 | N/A |
Description
Overview of the medicine
Darbepoetin alfa is an erythropoiesis-stimulating protein closely related to erythropoietin. It is used to treat anemia associated with chronic kidney disease and chemotherapy-induced anemia.
Uses & Indications
Dosage
Adults
Initial 0.45 mcg/kg SC or IV once weekly, or 0.75 mcg/kg SC every two weeks. Doses adjusted to maintain Hb levels between 10-12 g/dL.
Elderly
No specific dosage adjustment, but careful monitoring.
Renal_impairment
Used to treat anemia in CKD patients. Dosage is adjusted based on hemoglobin levels.
How to Take
Subcutaneous (SC) or Intravenous (IV) injection. Administered by a healthcare professional. Do not shake.
Mechanism of Action
Darbepoetin alfa stimulates erythropoiesis by binding to erythropoietin receptors on progenitor cells in the bone marrow, leading to red blood cell production.
Pharmacokinetics
Onset
Hemoglobin levels typically begin to rise within 2-6 weeks.
Excretion
Primarily via catabolism. Minimal renal excretion of intact drug.
Half life
Approximately 25.3 hours (IV) to 48.8 hours (SC) in patients with chronic kidney disease.
Absorption
Subcutaneous administration leads to slower, prolonged absorption. IV administration is immediate. Bioavailability SC is 37-84%.
Metabolism
Catabolized like endogenous proteins.
Side Effects
Contraindications
- Uncontrolled hypertension.
- Pure red cell aplasia (PRCA) that begins after treatment with darbepoetin alfa or other erythropoietin protein drugs.
- Serious allergic reactions to darbepoetin alfa.
Drug Interactions
No significant drug-drug interactions
No significant drug-drug interactions have been identified with Darbepoetin Alfa.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light.
Overdose
Overdose may lead to polycythemia (excessive red blood cells). Phlebotomy may be performed if necessary.
Pregnancy & Lactation
Use during pregnancy only if potential benefit justifies potential risk to the fetus. Caution when administering to a nursing mother.
Side Effects
Contraindications
- Uncontrolled hypertension.
- Pure red cell aplasia (PRCA) that begins after treatment with darbepoetin alfa or other erythropoietin protein drugs.
- Serious allergic reactions to darbepoetin alfa.
Drug Interactions
No significant drug-drug interactions
No significant drug-drug interactions have been identified with Darbepoetin Alfa.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light.
Overdose
Overdose may lead to polycythemia (excessive red blood cells). Phlebotomy may be performed if necessary.
Pregnancy & Lactation
Use during pregnancy only if potential benefit justifies potential risk to the fetus. Caution when administering to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Hospitals, Pharmacies
Approval Status
Approved by major regulatory bodies
Patent Status
Generic available, patents expired in many regions
Clinical Trials
Extensive clinical trials support efficacy and safety in CKD and chemotherapy-induced anemia.
Lab Monitoring
- Hemoglobin
- Hematocrit
- Blood pressure
- Iron stores (ferritin, transferrin saturation)
Doctor Notes
- Closely monitor hemoglobin levels to avoid exceeding 12 g/dL.
- Assess iron status before and during treatment.
- Educate patients on potential risks, especially cardiovascular events.
Patient Guidelines
- Do not shake the vial/syringe.
- Report any signs of allergic reaction or blood clots immediately.
- Monitor blood pressure regularly.
Missed Dose Advice
Administer the missed dose as soon as remembered if it's within a day or two, then resume regular schedule. If it's close to the next scheduled dose, skip the missed dose and continue with the regular schedule. Do not double dose.
Driving Precautions
No specific precautions, but report any visual disturbances or seizures.
Lifestyle Advice
- Maintain a healthy diet, especially one rich in iron.
- Follow doctor's instructions regarding blood pressure control.
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Global Brand Names
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