Dasaren
Generic Name
Dasaren 100 mg Tablet
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dasaren 100 mg tablet | ৳ 400.00 | ৳ 2,000.00 |
Description
Overview of the medicine
Dasaren 100 mg Tablet contains Dasaren, a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and fever. It works by reducing the production of certain natural substances in the body that cause inflammation.
Uses & Indications
Dosage
Adults
Initially 100 mg twice daily, adjusted based on response; maximum 300 mg daily.
Elderly
Lower doses may be required; consult physician.
Renal_impairment
Use with caution; dose reduction may be necessary in severe impairment.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Dasaren inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are lipid compounds that mediate inflammation, pain, and fever. By inhibiting their synthesis, Dasaren reduces these symptoms.
Pharmacokinetics
Onset
Analgesic effect usually within 30-60 minutes, anti-inflammatory effect may take several days.
Excretion
Mainly excreted in the urine as metabolites, with a small portion excreted in feces.
Half life
Approximately 2-4 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 1-2 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes (e.g., CYP2C9).
Side Effects
Contraindications
- Hypersensitivity to Dasaren or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Severe heart failure
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Diuretics
Reduced diuretic and antihypertensive effects.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm. Use with caution during the first two trimesters and lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by national regulatory authority (e.g., DGDA)
Patent Status
Patent expired
Clinical Trials
Extensive clinical trials demonstrated efficacy in pain and inflammation management with a favorable safety profile compared to placebo. Phase III trials involved over 1000 patients.
Lab Monitoring
- Complete blood count (CBC)
- Renal function tests (e.g., creatinine, BUN)
- Liver function tests (e.g., ALT, AST)
Doctor Notes
- Prescribe with caution in patients with history of cardiovascular disease or GI disorders.
- Monitor renal and hepatic function during long-term therapy.
- Educate patients on NSAID-associated risks.
Patient Guidelines
- Do not exceed the recommended dose.
- Take with food to avoid stomach upset.
- Inform your doctor about all other medications you are taking.
- Report any signs of gastrointestinal bleeding (e.g., black stools) immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness. Patients should be advised to exercise caution when driving or operating machinery until they know how Dasaren affects them.
Lifestyle Advice
- Avoid alcohol consumption while on this medication.
- Maintain adequate hydration.
- Limit activities requiring high alertness if experiencing dizziness.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.