Daxetin
Generic Name
Dapoxetine
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| daxetin 30 mg tablet | ৳ 30.00 | ৳ 120.00 |
Description
Overview of the medicine
Daxetin 30 mg tablet contains Dapoxetine, a selective serotonin reuptake inhibitor (SSRI) used for the treatment of premature ejaculation in adult men aged 18 to 64 years.
Uses & Indications
Dosage
Adults
Initial dose is 30 mg, taken orally as needed approximately 1 to 3 hours prior to anticipated sexual activity. Do not take more than one dose in 24 hours. If 30 mg is insufficient and side effects are acceptable, the dose may be increased to 60 mg.
Elderly
Not recommended for patients 65 years or older due to limited data.
Renal_impairment
Caution is advised in patients with mild to moderate renal impairment. Not recommended in severe renal impairment.
How to Take
Taken orally with a full glass of water, with or without food, approximately 1 to 3 hours prior to anticipated sexual activity.
Mechanism of Action
Dapoxetine inhibits the serotonin transporter, increasing serotonin's action at the postsynaptic cleft and thereby inhibiting the ejaculatory reflex, leading to delayed ejaculation.
Pharmacokinetics
Onset
Effect typically observed within 1-3 hours after administration.
Excretion
Mainly via urine, as metabolites.
Half life
Terminal half-life is approximately 1.5-2 hours, with an active metabolite having a longer half-life.
Absorption
Rapidly absorbed. Peak plasma concentration is reached within 1-2 hours.
Metabolism
Primarily hepatic, via CYP2D6 and CYP3A4, to various active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to dapoxetine or any excipients.
- Significant pathological cardiac conditions (e.g., heart failure, conduction abnormalities like AV block, sick sinus syndrome).
- Concomitant use with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOIs.
- Concomitant use with thioridazine or within 14 days of discontinuing thioridazine.
- Concomitant use with serotonin reuptake inhibitors (SSRIs, SNRIs, TCAs) or within 14 days of discontinuing these agents.
- Moderate to severe hepatic impairment.
- Concomitant use with potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, telithromycin, nefazodone, nelfinavir, saquinavir).
Drug Interactions
Alcohol
Exacerbates neurocognitive effects (e.g., dizziness, somnolence) and may increase syncope risk. Avoid.
Thioridazine
Increased QT prolongation and ventricular arrhythmias; contraindicated.
SSRIs/SNRIs/TCAs
Increased risk of serotonin syndrome; contraindicated.
Monoamine Oxidase Inhibitors (MAOIs)
Increased risk of serotonin syndrome; contraindicated.
Potent CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
Significantly increased dapoxetine exposure; contraindicated.
Moderate CYP3A4 Inhibitors (e.g., Erythromycin, Verapamil, Diltiazem)
Increased dapoxetine exposure; caution, consider lower starting dose.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, somnolence, tremor, nausea, and vomiting. Treatment is symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Daxetin is not indicated for use in women.
Side Effects
Contraindications
- Hypersensitivity to dapoxetine or any excipients.
- Significant pathological cardiac conditions (e.g., heart failure, conduction abnormalities like AV block, sick sinus syndrome).
- Concomitant use with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOIs.
- Concomitant use with thioridazine or within 14 days of discontinuing thioridazine.
- Concomitant use with serotonin reuptake inhibitors (SSRIs, SNRIs, TCAs) or within 14 days of discontinuing these agents.
- Moderate to severe hepatic impairment.
- Concomitant use with potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, telithromycin, nefazodone, nelfinavir, saquinavir).
Drug Interactions
Alcohol
Exacerbates neurocognitive effects (e.g., dizziness, somnolence) and may increase syncope risk. Avoid.
Thioridazine
Increased QT prolongation and ventricular arrhythmias; contraindicated.
SSRIs/SNRIs/TCAs
Increased risk of serotonin syndrome; contraindicated.
Monoamine Oxidase Inhibitors (MAOIs)
Increased risk of serotonin syndrome; contraindicated.
Potent CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
Significantly increased dapoxetine exposure; contraindicated.
Moderate CYP3A4 Inhibitors (e.g., Erythromycin, Verapamil, Diltiazem)
Increased dapoxetine exposure; caution, consider lower starting dose.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, somnolence, tremor, nausea, and vomiting. Treatment is symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Daxetin is not indicated for use in women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive randomized, placebo-controlled clinical trials have demonstrated the efficacy and safety of dapoxetine in adult men with premature ejaculation across various populations.
Lab Monitoring
- No specific routine lab monitoring is required.
Doctor Notes
- Carefully assess patient's cardiovascular health and history of syncope before prescribing.
- Educate patient on the on-demand dosing regimen and the importance of taking it with a full glass of water to reduce orthostatic effects.
- Stress the contraindication with MAOIs and other serotonergic agents to prevent serotonin syndrome.
- Not indicated for daily continuous use.
Patient Guidelines
- Take 1-3 hours before sexual activity.
- Do not take more than once every 24 hours.
- Swallow tablet whole with a full glass of water to minimize side effects like dizziness.
- Avoid alcohol while taking this medicine.
- Do not use if you have severe heart or liver problems, or are taking certain other medications. Consult your doctor.
Missed Dose Advice
Daxetin is taken on-demand, not on a regular dosing schedule. Therefore, a missed dose is not applicable. Do not take more than one dose in 24 hours.
Driving Precautions
Daxetin may cause dizziness, somnolence, syncope, or blurred vision. Patients should be advised to exercise caution or avoid driving or operating hazardous machinery if they experience these effects.
Lifestyle Advice
- Maintain a healthy lifestyle, including regular exercise and a balanced diet.
- Communicate openly with your partner and healthcare provider about your condition and treatment.
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